Volume 19 Issue 4
Apr.  2021
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 558-560
QIU Feng, SONG Chun-yan, QIN Fu-chuang, TIAN Si-qi, HUANG Rong, MA Xi-lie, ZENG Jian-ping. Mangiferin relieves Staphylococcus aureus-induced pneumonia by inhibiting the NF-κB signalling pathway[J]. Chinese Journal of General Practice, 2021, 19(4): 558-560. doi: 10.16766/j.cnki.issn.1674-4152.001860
Citation: QIU Feng, SONG Chun-yan, QIN Fu-chuang, TIAN Si-qi, HUANG Rong, MA Xi-lie, ZENG Jian-ping. Mangiferin relieves Staphylococcus aureus-induced pneumonia by inhibiting the NF-κB signalling pathway[J]. Chinese Journal of General Practice, 2021, 19(4): 558-560. doi: 10.16766/j.cnki.issn.1674-4152.001860
shu

Mangiferin relieves Staphylococcus aureus-induced pneumonia by inhibiting the NF-κB signalling pathway

doi: 10.16766/j.cnki.issn.1674-4152.001860
  • 1.

    Department of Emergency Medicine, Shulan (Hangzhou) Hospital, Hangzhou, Zhejiang 310006, China

Funds:

 LGF19H090007

  • Received Date: 2020-06-08
    Available Online: 2022-02-16
    Abstract
  •   Objective  This study aimed to investigate the effect of mangiferin on Staphylococcus aureus-induced pneumonia and on the NF-κB signalling pathway.  Methods  Fifty Balb/c male mice were randomly divided into five groups by the random number method, with 10 mice in each group: control group, S. aureus group and mangiferin (15, 30 and 60 mg/kg) group. After 1 h of S. aureus-induced modelling, the mangiferin group was given intraperitoneal injection of mangiferin. After 12 h, the alveolar lavage fluid and lung tissues of each group were collected. The TNF-α and IL-1β levels of alveolar lavage fluid, wet-to-dry ratio (W/D), activity of pulmonary myeloperoxidase (MPO) and the p65 level of lung tissue were measured.  Results  Compared with the model group, low, middle and high dose of mangiferin could effectively reduce TNF-α, IL-1β, W/D and MPO in a quantitative manner (all P < 0.05). The TNF-α, IL-1β, W/D and MPO of the high-dose mangiferin group were (3.25±0.52) ng/mL, (3.53±0.65) ng/mL, 7.16±0.34 and (3.15±0.61) U/g, respectively, which were significantly lower than those of the model group[(5.28±0.93) ng/mL, (6.63±0.85) ng/mL, 10.55±0.92, (6.74±0.85) U/g, t=6.025, P < 0.001; t=9.161, P < 0.001; t=10.930, P < 0.001; t=10.850, P < 0.001]. Mechanism research showed that mangiferin could effectively down-regulate p-p65 induced by S. aureus.  Conclusion  Mangiferin could improve S. aureus-induced pneumonia in mice by inhibiting the NF-κB signalling pathway.

     

    • FullText(HTML)
  • loading
    • References(15)
  • [1]
    陈丹, 齐颖. 乳果糖联合益生菌对老年重症肺炎患者肠道微生态的影响[J]. 中华全科医学, 2019, 17(4): 666-669. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201904040.htm
    [2]
    肖燕燕, 李建宁, 蒋雪梅. 超声在常见肺部疾病诊断中的应用[J]. 中国中西医结合影像学杂志, 2020, 18(3): 316-320. doi: 10.3969/j.issn.1672-0512.2020.03.030
    [3]
    黄佳伟, 鲁娴娴, 崔海燕, 等. PM2.5通过NF-κB/NLRP3途径促进金黄色葡萄球菌肺炎的研究[J]. 生态毒理学报, 2019, 14(5): 133-143. https://www.cnki.com.cn/Article/CJFDTOTAL-STDL201905012.htm
    [4]
    GAO H, KANG N, HU C, et al. Ginsenoside Rb1 exerts anti-inflammatory effects in vitro and in vivo by modulating toll-like receptor 4 dimerization and NF-kB/MAPKs signaling pathways[J]. Phytomedicine, 2020, 69: 153197. doi: 10.1016/j.phymed.2020.153197
    [5]
    李刚, 余朝萍, 龚厚文, 等. 芒果苷减轻缺氧复氧所致人心肌细胞损伤[J]. 中国病理生理杂志, 2020, 36(4): 657-662. doi: 10.3969/j.issn.1000-4718.2020.04.011
    [6]
    王豕辰, 徐珺, 董恒, 等. 芒果苷抑制金黄色葡萄球菌诱导的细胞凋亡[J]. 北京农学院学报, 2020, 35(2): 39-42. https://www.cnki.com.cn/Article/CJFDTOTAL-BNXB202002010.htm
    [7]
    王明宇, 陈瑞家. 芒果苷通过下调热休克蛋白90表达抑制肝癌HepG2细胞增殖研究[J]. 中国临床药理学杂志, 2019, 35(23): 3052-3055. https://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ201923030.htm
    [8]
    陈星, 夏晓冬, 童德银, 等. 芒果苷改善肝损伤模型小鼠肝功能实验研究[J]. 中国药业, 2019, 28(10): 17-20. doi: 10.3969/j.issn.1006-4931.2019.10.006
    [9]
    郭伟, 张同强, 徐勇胜. 肺炎支原体肺炎患儿TNF-α、IFN-γ和IL-4细胞因子水平的变化[J]. 中国现代医学杂志, 2018, 28(23): 65-68. doi: 10.3969/j.issn.1005-8982.2018.23.014
    [10]
    韩小胜, 黄会, 魏小斌. 重症肺炎链球菌感染患儿血清TNF-α、IL-1β、IL-6的表达水平及意义[J]. 国际检验医学杂志, 2018, 39(9): 1068-1070, 1073. doi: 10.3969/j.issn.1673-4130.2018.09.013
    [11]
    刘钢, 李然然, 李萍萍, 等. 炎症因子在大叶性肺炎患儿支气管肺泡灌洗液及血清中的表达及临床意义[J]. 现代生物医学进展, 2017, 17(20): 3917-3920. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201720028.htm
    [12]
    李帅, 方磊, 王炯, 等. 金黄色葡萄球菌通过TLR2/PI3K信号诱导巨噬细胞的炎症反应和自噬[J]. 细胞与分子免疫学杂志, 2017, 33(9): 1160-1164. https://www.cnki.com.cn/Article/CJFDTOTAL-XBFM201709002.htm
    [13]
    VANHECKE C, GIRERD R, DUJARDIN M, et al. Retrospective study of pneumonia due to Panton-Valentine leukocidin-producing Staphylococcus aureus in Reunion[J]. Med Mal Infect, 2019, 49(7): 534-539. doi: 10.1016/j.medmal.2019.01.010
    [14]
    胡正权, 孙欣娜, 杨青. microRNA 20a通过核因子-κB信号通路影响肺炎模型幼鼠炎症水平的机制研究[J]. 临床和实验医学杂志, 2020, 19(8): 815-819. doi: 10.3969/j.issn.1671-4695.2020.08.009
    [15]
    ESPIN I M, AGUILERA-ALONSO D, GARCIA-PEREA A, et al. Methicillin-resistant Staphylococcus aureus community-acquired pneumonia in infants[J]. Enferm Infec Micrcl Clin, 2019, 37(8): 551-552. doi: 10.1016/j.eimc.2018.11.005
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (207) PDF downloads(2) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return