Volume 19 Issue 4
Apr.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 577-580, 606
SONG Zhen-dong, WEN Shao-yun, LI Xin. Application of fluid infusion under Flotrac/Vigileo monitoring in laparoscopic radical cystectomy for bladder cancer in elderly patients[J]. Chinese Journal of General Practice, 2021, 19(4): 577-580, 606. doi: 10.16766/j.cnki.issn.1674-4152.001865
Citation: SONG Zhen-dong, WEN Shao-yun, LI Xin. Application of fluid infusion under Flotrac/Vigileo monitoring in laparoscopic radical cystectomy for bladder cancer in elderly patients[J]. Chinese Journal of General Practice, 2021, 19(4): 577-580, 606. doi: 10.16766/j.cnki.issn.1674-4152.001865
shu

Application of fluid infusion under Flotrac/Vigileo monitoring in laparoscopic radical cystectomy for bladder cancer in elderly patients

doi: 10.16766/j.cnki.issn.1674-4152.001865
  • 1.

    Department of Anesthesiology, Taizhou Central Hospital, Taizhou, Zhejiang 318000, China

Funds:

 LGF19H050004

  • Received Date: 2020-10-21
    Available Online: 2022-02-16
    Abstract
  •   Objective  This study aimed to investigate the effects of infusion under Flotrac/Vigileo monitoring on postoperative recovery and inflammatory response in patients undergoing laparoscopic radical cystectomy for bladder cancer.  Methods  A total of 160 patients undergoing laparoscopic radical cystectomy for bladder cancer in Taizhou Central Hospital from January 2019 to December 2019 were selected and divided into group A and group B by the random number method, with 80 patients in each group. Group A was given liquid infusion based on "4/2/1" rule for Ⅳ, and group B was given liquid infusion according to Flotrac/Vigileo monitoring results. Peripheral venous blood was collected before surgery, 1 day after surgery, 3 days after surgery and 7 days after surgery. Serum samples were separated. Serum levels of tumour necrosis factor-α (TNF-α), interleukin-2 (IL-2) and IL-6 were determined by double-antibody ELISA.  Results  No significant differences in anaesthesia time, operation duration, postoperative recovering time, total fluid volume, blood loss and urine volume, haemodynamics, complications, length of hospital stay, bladder volume, maximum urine flow rate and bladder pressure were found between the two groups (all P > 0.05). The amount of colloid Ⅳ solution in group B [(1 291.45±224.83) mL] was higher than that in group A (P < 0.05), and the amount of crystalloid Ⅳ solutions in group B [(992.13±234.15) mL] was lower than that in group A (P < 0.05). The anal exhaust time of group B [(61.35±14.16) h], time to post-operative ambulation [(6.34±1.42) h] and time of resuming feeding [(3.51±1.07) h] were all shorter than those of group A (all P < 0.05). Compared with preoperation, the serum levels of TNF-α and IL-6 increased and IL-2 decreased in the two groups at 1 and 3 days after operation (P < 0.05). The serum levels of TNF-α and IL-6 in group B were higher than those in group A, while the serum level of IL-2 was lower than that in group A (P < 0.05).  Conclusion  Infusion under Flotrac/Vigileo monitoring can promote postoperative recovery and inhibit perioperative inflammatory response in patients undergoing radical laparoscopic radical bladder cancer surgery.

     

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