Volume 19 Issue 4
Apr.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 593-595, 652
HUANG Dan-yun, CHEN Yue, SHI Hai-lan, SHEN Xiao-fen. Study on the reducing toxicity and enhancing efficacy of Jiedu Quyu Zishen Recipe in treating systemic lupus erythematosus with hormone[J]. Chinese Journal of General Practice, 2021, 19(4): 593-595, 652. doi: 10.16766/j.cnki.issn.1674-4152.001869
Citation: HUANG Dan-yun, CHEN Yue, SHI Hai-lan, SHEN Xiao-fen. Study on the reducing toxicity and enhancing efficacy of Jiedu Quyu Zishen Recipe in treating systemic lupus erythematosus with hormone[J]. Chinese Journal of General Practice, 2021, 19(4): 593-595, 652. doi: 10.16766/j.cnki.issn.1674-4152.001869
shu

Study on the reducing toxicity and enhancing efficacy of Jiedu Quyu Zishen Recipe in treating systemic lupus erythematosus with hormone

doi: 10.16766/j.cnki.issn.1674-4152.001869

  • Department of Dermatology, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310005, China

Funds:

 82004371

  • Received Date: 2020-12-07
    Available Online: 2022-02-16
    Abstract
  •   Objective  To observe the clinical efficacy and side effect of Jiedu Quyu Zishen Recipe prescription on hormone therapy for systemic lupus erythematosus (SLE).  Methods  A total of 110 patients with moderate systemic lupus erythematosus were divided into control group (n=55) and study group (n=55) by random number table. Patients in the control group were treated with prednisone acetate, and patients in the study group were given Jiedu Quyu Zishen Recipe supplemented with prednisone acetate. The serum levels of antinuclear antibody (ANA), anti-double stranded DNA (anti-dsDNA), IgA and IgG of the two groups were compared before and after treatment. The SLE disease activity index (SLEDAI) score was conducted to detect the urine protein level, evaluate the clinical efficacy of systemic lupus erythematosus after treatment, and observe the adverse drug reactions during treatment.  Results  After treatment, the levels of ANA, anti-dsDNA, IgA and IgG in the study group [(1.74±0.18) mg/mL, (0.99±0.10) mg/mL, (1.45±0.12) mg/mL and (8.57±0.74) mg/mL] were significantly lower than those in the control group [(2.15±0.21) mg/mL, (1.32±0.16) mg/mL, (1.78±0.14) mg/mL and (11.57±1.02) mg/mL], P < 0.05. After treatment, SLEDAI score and urine protein content at 24 h [(4.57±0.36) points and (0.67±0.06) g] in the study group were significantly lower than those in the control group [(5.18±0.49) points and (0.93±0.08) g], P < 0.05. The overall response rate of systemic lupus erythematosus in the study group (96.67%) was significantly higher than that in the control group (83.33%), P=0.015. The overall incidence of adverse drug reactions in the study group (11.63%) was significantly lower than that in the control group (33.33%), P=0.004.  Conclusion  Jiedu Quyu Zishen Recipe can assist prednisone acetate in the treatment of systemic lupus erythematosus. On the basis of reducing the maintenance dose of prednisone acetate, it can effectively relieve clinical symptoms, improve curative effect, and reduce adverse reactions of hormone drugs. It has the effect of enhancing and reducing toxicity, and is worthy of clinical promotion.

     

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    • References(19)
  • [1]
    陆前进, 罗帅寒天. 系统性红斑狼疮的诊疗进展[J]. 中华皮肤科杂志, 2018, 51(1): 1-4. https://www.cnki.com.cn/Article/CJFDTOTAL-NMYX201905035.htm
    [2]
    朱亚男, 张文. 系统性红斑狼疮并发无菌性骨坏死与糖皮质激素使用相关性的荟萃分析[J]. 中华临床免疫和变态反应杂志, 2018, 12(2): 178-184. https://www.cnki.com.cn/Article/CJFDTOTAL-OZHL201802008.htm
    [3]
    徐丽玲, 郭乾育, 蔡小燕, 等. 糖皮质激素治疗系统性红斑狼疮患者的现况调查[J]. 中华内科杂志, 2017, 56(4): 290-294. doi: 10.3760/cma.j.issn.0578-1426.2017.04.010
    [4]
    许诚. 不同剂量糖皮质激素治疗系统性红斑狼疮的临床疗效及对骨骼的影响[J]. 医学综述, 2017, 23(6): 1238-1241, 1245. doi: 10.3969/j.issn.1006-2084.2017.06.044
    [5]
    谢长好, 李志军. 系统性红斑狼疮的诊断与治疗[J]. 中华全科医学, 2020, 18(4): 527-528. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY202004002.htm
    [6]
    陈波, 梁洁. 不同剂量糖皮质激素治疗系统性红斑狼疮的效果比较分析[J]. 中国当代医药, 2019, 26(9): 76-78. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGUD201909022.htm
    [7]
    闵月. 糖皮质激素联合羟氯喹治疗系统性红斑狼疮效果观察[J]. 皮肤病与性病, 2018, 40(6): 834-835. https://www.cnki.com.cn/Article/CJFDTOTAL-PFBX201806035.htm
    [8]
    黄玉琼, 张亚敏, 陶娟. 糖皮质激素在系统性红斑狼疮中的应用及研究现状[J]. 皮肤科学通报, 2018, 35(3): 296-304. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXW201803011.htm
    [9]
    徐玲, 舒畅, 范中光. 糖皮质激素联合羟氯喹治疗系统性红斑狼疮皮疹康复的疗效观察[J]. 反射疗法与康复医学, 2020, 29(4): 101-102. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYX201004043.htm
    [10]
    刘思娣, 黄传兵, 石周珍, 等. 系统性红斑狼疮相关骨质疏松的研究进展[J]. 中国骨质疏松杂志, 2018, 24(5): 671-675. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZS201805021.htm
    [11]
    周彬. 红斑狼疮患者应用糖皮质激素不良反应的观察及护理[J]. 养生保健指南, 2018(42): 80.
    [12]
    韩淑贞, 杜羽. 中医治疗系统性红斑狼疮关节痛的临床研究进展[J]. 中国中医急症, 2020, 29(4): 743-745, 749. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJZ202004052.htm
    [13]
    朱月玲, 吴芳. 系统性红斑狼疮中医证型及变化研究概况[J]. 中华中医药杂志, 2018, 33(7): 2973-2975. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201807073.htm
    [14]
    张佩莲. 系统性红斑狼疮的中医药研究进展[J]. 皮肤科学通报, 2018, 35(3): 322-327. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYXW201803015.htm
    [15]
    朱竹菁, 苏励. 养阴化瘀方联合强化西药方案治疗活动期系统性红斑狼疮疗效研究[J]. 中国中医急症, 2019, 28(10): 1788-1791. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJZ201910024.htm
    [16]
    徐晨婷, 余毅, 李海昌, 等. 解毒祛瘀滋肾方加减对激素治疗系统性红斑狼疮不同阶段的增效减毒作用[J]. 云南中医学院学报, 2016, 39(3): 68-71. https://www.cnki.com.cn/Article/CJFDTOTAL-YNZY201603017.htm
    [17]
    吴德鸿, 范永升, 谢冠群, 等. 解毒祛瘀滋肾方对小鼠单核巨噬细胞Toll样受体9信号通路的影响[J]. 中国中西医结合杂志, 2015, 35(4): 466-470. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZXJ201504021.htm
    [18]
    吴德鸿, 徐莉, 李正富, 等. 解毒祛瘀滋肾方对MRL/lpr狼疮小鼠BAFF/BAFF-R信号通路的影响[J]. 中华中医药杂志, 2020, 35(4): 1728-1732. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY202004028.htm
    [19]
    杨辉, 谢志军, 李海昌, 等. 中医药在系统性红斑狼疮激素撤减过程中的问题分析与对策[J]. 中华中医药杂志, 2018, 33(2): 588-591. https://www.cnki.com.cn/Article/CJFDTOTAL-BXYY201802052.htm
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