Volume 19 Issue 4
Apr.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 607-610
CHEN Ru-ru, LUO Hou-jiang, YANG Jun, JIA Wen-ting, WANG Lei, GUO Hong-hui. Application of low molecular weight heparin combined with fresh frozen plasma in the treatment of coagulation abnormalities in critically ill neonates[J]. Chinese Journal of General Practice, 2021, 19(4): 607-610. doi: 10.16766/j.cnki.issn.1674-4152.001873
Citation: CHEN Ru-ru, LUO Hou-jiang, YANG Jun, JIA Wen-ting, WANG Lei, GUO Hong-hui. Application of low molecular weight heparin combined with fresh frozen plasma in the treatment of coagulation abnormalities in critically ill neonates[J]. Chinese Journal of General Practice, 2021, 19(4): 607-610. doi: 10.16766/j.cnki.issn.1674-4152.001873
shu

Application of low molecular weight heparin combined with fresh frozen plasma in the treatment of coagulation abnormalities in critically ill neonates

doi: 10.16766/j.cnki.issn.1674-4152.001873
  • 1.

    Department of Paediatrics, the Second Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, China

Funds:

 KJ2019A0342

 BYKY2019158ZD

 BYKY2019155ZD

  • Received Date: 2020-08-13
    Available Online: 2022-02-16
    Abstract
  •   Objective  To investigate the clinical effects of low molecular weight heparin combined with fresh frozen plasma in the treatment of abnormal coagulation functions in critically ill neonates.  Methods  Seventy-two critically ill children with coagulopathy admitted to the neonatal ward of The Second Affiliated Hospital of Bengbu Medical College from February 2019 to August 2020 were selected and divided into an observation group (n=35) and a control group (n=37). Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), D-Dimer (D-D) and platelet (PLT) levels were monitored. The control group received conventional treatment, whereas the observation group was administered with low molecular weight heparin and fresh frozen plasma on the basis of conventional treatment. The aforementioned indicators were retested after 72 h of treatment. The clinical efficacy, coagulation function indexes and complication incidence of the two groups were compared.  Results  The effective rate of the observation group was significantly higher than that of the control group after treatment (P < 0.05). No significant difference was observed in the levels of PT, APTT, FIB, TT, D-D and PLT between the two groups before treatment (all P>0.05). After treatment, the PT, APTT, TT and D-D levels of the observation group were significantly lower than those of the control group (all P < 0.05). By contrast, the FIB level of the observation group was significantly higher than that of the control group (P < 0.05). After treatment, the PLT level of the observation group was lower than that of the control group, but the difference was not statistically significant (P>0.05). After treatment, the levels of PT, APTT, TT and D-D in both groups were significantly lower than those before the treatment (all P < 0.05). Furthermore, the level of FIB was significantly higher than that before the treatment (P < 0.05). The levels of PLT in both groups after the treatment were significantly higher than those before thetreatment (P < 0.05). After the treatment, the incidence of intracranial haemorrhage, gastrointestinal hemorrhage and pulmonary hemorrhage in the observation group was lower than that in the control group, but the difference was not statistically significant (all P>0.05).  Conclusion  Early intervention with low molecular weight heparin combined with fresh frozen plasma in the treatment of abnormal coagulation functions in critically ill newborns can improve clinical symptoms and restore coagulation functions. This intervention has good clinical effects.

     

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