Volume 19 Issue 4
Apr.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 611-613
LYU Ying, YE Li-yan, FAN Xu-fei, ZHENG Xiu-juan. Expression of P53 and lncRNA TINCR in placental trophoblast cells and apoptosis of placental trophoblast cells in preeclampsia[J]. Chinese Journal of General Practice, 2021, 19(4): 611-613. doi: 10.16766/j.cnki.issn.1674-4152.001874
Citation: LYU Ying, YE Li-yan, FAN Xu-fei, ZHENG Xiu-juan. Expression of P53 and lncRNA TINCR in placental trophoblast cells and apoptosis of placental trophoblast cells in preeclampsia[J]. Chinese Journal of General Practice, 2021, 19(4): 611-613. doi: 10.16766/j.cnki.issn.1674-4152.001874
shu

Expression of P53 and lncRNA TINCR in placental trophoblast cells and apoptosis of placental trophoblast cells in preeclampsia

doi: 10.16766/j.cnki.issn.1674-4152.001874

  • Department of Obstetrics, Jinhua Central Hospital, Jinhua, Zhejiang 321000, China

Funds:

 LQ19H040002

  • Received Date: 2020-11-21
    Available Online: 2022-02-16
    Abstract
  •   Objective  This study aimed to investigate the expression of P53 and lncRNA TINCR and apoptosis of placental trophoblast cells in preeclampsia.  Methods  A total of 98 cases of preeclampsia who were hospitalised in Jinhua Central Hospital from June 2018 to June 2020 were included in the study; 50 normal pregnant women were selected as the control group. Semi-quantitative reverse transcription polymerase chain reaction was used to detect the expression of P53 and lncRNA TINCR, and the expression of Bax and Bcl-2 was detected by chemiluminescence. The expression of P53, lncRNA TINCR, Bax and Bcl-2 protein was compared.  Results  The relative expression of p53 (5.09±1.26) and lncRNA TINCR (3.79±0.83) in the preeclampsia group was higher than that in the control group (1.32±0.36 and 1.09±0.31, t=20.699, 22.195, all P < 0.05). The expression of Bax in the preeclampsia group (0.65±0.14) was lower than that in control group (1.28±0.36), whereas the expression of Bcl-2 (1.26±0.16) was higher than the control group (0.67±0.23, t=15.248, 18.208, all P < 0.05).  Conclusion  The expression of P53 and lncRNA TINCR in placental trophoblast cells of preeclampsia is abnormally increased, and the apoptotic level of placental trophoblast cells is increased.

     

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