Volume 19 Issue 4
Apr.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 614-616, 620
CHEN Shuang, DONG Huai-fu, CHEN Xin, QU Se-hua. Application value of heparin binding protein in the early diagnosis of sepsis in children[J]. Chinese Journal of General Practice, 2021, 19(4): 614-616, 620. doi: 10.16766/j.cnki.issn.1674-4152.001875
Citation: CHEN Shuang, DONG Huai-fu, CHEN Xin, QU Se-hua. Application value of heparin binding protein in the early diagnosis of sepsis in children[J]. Chinese Journal of General Practice, 2021, 19(4): 614-616, 620. doi: 10.16766/j.cnki.issn.1674-4152.001875
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Application value of heparin binding protein in the early diagnosis of sepsis in children

doi: 10.16766/j.cnki.issn.1674-4152.001875

  • Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0378

 BYKY18116

  • Received Date: 2020-07-21
    Available Online: 2022-02-16
    Abstract
  •   Objective  To examine the clinical value of heparin-binding protein (HBP) in the early diagnosis and evaluation of childhood sepsis.  Methods  Total 61 children with sepsis who were hospitalized in the First Affiliated Hospital of Bengbu Medical College from January 2019 to February 2020 were selected and divided into sepsis group (35 cases), severe sepsis group (16 cases) and septic shock group (10 cases) according to the severity of the disease. Meanwhile, 30 children who were hospitalized due to local infection were set as local infection group. The levels of HBP, procalcitonin (PCT), and C-reactive protein (CRP) were compared per group, and the efficacy of each indicator in diagnosing sepsis was compared and analysed.  Results  The overall differences amongst the four groups were statistically significant (F=162.024, 78.944, 10.982, all P < 0.05). The levels of HBP were (19.74±15.2) μg/L, (34.79±14.08) μg/L, (57.42±14.63) μg/L, (191.20±53.28) μg/L; the levels of PCT were (1.33±1.07) ng/mL, (3.38±2.63) ng/mL, (9.93±6.65) ng/mL, (18.13±1.45) ng/mL, respectively, and increased with the aggravation of the disease (all P < 0.05). No statistically significant difference in CRP level existed between the septic shock group [(79.47±18.94) mg/L] and the severe sepsis group [(73.60±26.22) mg/L, P>0.05], and pausal differences between the other groups were statistically significant (all P < 0.05). ROC curve analysis showed that the maximum area under the curve (AUC) was 0.922, sensitivity was 72.13%, and specificity was 96.67% when the three indicators were combined to diagnose sepsis.  Conclusion  Serum HBP has good value in diagnosing childhood sepsis, and the combined detection of the three indices is better than single detection.

     

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