Volume 19 Issue 4
Apr.  2021
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(4): 674-678
TAO Run, GUAN Han, LIU Yan-shen, ZHOU Wen-sheng. Multivariate analysis of prognosis and nomogram construction of cystadenocarcinoma based on SEER database[J]. Chinese Journal of General Practice, 2021, 19(4): 674-678. doi: 10.16766/j.cnki.issn.1674-4152.001891
Citation: TAO Run, GUAN Han, LIU Yan-shen, ZHOU Wen-sheng. Multivariate analysis of prognosis and nomogram construction of cystadenocarcinoma based on SEER database[J]. Chinese Journal of General Practice, 2021, 19(4): 674-678. doi: 10.16766/j.cnki.issn.1674-4152.001891
shu

Multivariate analysis of prognosis and nomogram construction of cystadenocarcinoma based on SEER database

doi: 10.16766/j.cnki.issn.1674-4152.001891

  • Department of Urology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 1808085MH293

  • Received Date: 2020-07-15
    Available Online: 2022-02-16
    Abstract
  •   Objective  This study aimed to establish a nomogram model that can individually predict the prognosis of patients with bladder adenocarcinoma (ACB) by studying the independent prognostic risk factors.  Methods  Clinical data of patients diagnosed with ACB from 2004 to 2015 in the SEER database were collected for screening. A total of 659 patients with adenocarcinoma who met the study conditions were included for retrospective analysis. COX univariate regression analysis was performed on all variables using Empower stat software, and P < 0.05 was analysed. Variables of 0.05 were included in COX multivariate regression analysis. Independent prognostic risk factors determined in COX multivariate regression analysis were constructed into a survival nomogram model using R language. The bootstrap method was used to perform 1 000 times of equal number of repeated sampling to verify the model.  Results  Age > 70 years, tumour size>3 cm, T3, T4, N1, N2 and M1 were independent risk factors affecting the survival time of patients. The established alignment curve of the nomogram has a high consistency with the ideal curve and high applicability and accuracy after internal verification.  Conclusion  In this study, the seer database was used to determine the independent risk factors for the prognosis of ACB patients, and the first nomogram model was established to individually predict the survival prognosis of ACB patients and guide clinicians in selecting reasonable treatment options and conducting accurate individualised assessment of the prognosis of different patients.

     

    • FullText(HTML)
  • loading
    • References(18)
  • [1]
    NING J Z, YU W M, CHENG F, et al. MiR-425 promotes migration and invasion in bladder cancer by targeting Dickkopf 3[J]. J Cancer, 2020, 11(12): 3424-3432. doi: 10.7150/jca.40233
    [2]
    江明友, 万明发, 洪钟亮. 尿液BLCA-4与BLCA-1水平在膀胱癌诊断及复发检测中的价值[J]. 中华全科医学, 2018, 16(4): 570-572. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201804019.htm
    [3]
    MOSCHINI M, D'ANDREA D, KORN S, et al. Characteristics and clinical significance of histological variants of bladder cancer[J]. Nat Rev Urol, 2017, 14(Suppl 2): 651-668. http://www.nature.com/articles/nrurol.2017.125.pdf
    [4]
    江明友, 万明发, 洪钟亮. 尿液BLCA-4与BLCA-1水平在膀胱癌诊断及复发检测中的价值[J]. 中华全科医学, 2018, 16(4): 570-572. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201804019.htm
    [5]
    VASUDEVAN G, BISHNU A, SINGH B M K, et al. Bladder adenocarcinoma: a persisting diagnostic dilemma[J]. J Clin Diagn Res, 2017, 11(3): ER01-ER04. http://jcdr.net/articles/PDF/9536/24590_CE[Ra1]_F(DK)_PF1(SY_RK)_PFA(P)_PF2(P_NESY).pdf
    [6]
    SIEGEL REBECCA L, MILLER KIMBERLY D, JEMAL AHMEDIN. Cancer statistics, 2019[J]. CA Cancer J Clin, 2019, 69(1): 7-34. doi: 10.3322/caac.21551
    [7]
    郭晓雪, 刘云鹤, 李文涛, 等. 膀胱原发性腺癌1例报告并文献复习[J]. 亚太传统医药, 2018, 14(7): 124-125. https://www.cnki.com.cn/Article/CJFDTOTAL-YTCT201807045.htm
    [8]
    许晖阳, 王道虎. 膀胱腺癌的诊治进展[J]. 国际泌尿系统杂志, 2017, 37(2): 271-273. doi: 10.3760/cma.j.issn.1673-4416.2017.02.032
    [9]
    SZARVAS T, MÔDOS O, NIEDWOROK C, et al. Clinical, prognostic, and therapeutic aspects of urachal carcinoma-A comprehensive review with meta-analysis of 1, 010 cases[J]. Urol Oncol, 2016, 34(9): 388-398. doi: 10.1016/j.urolonc.2016.04.012
    [10]
    顾伟平, 徐耀庭, 李杜渐, 等. 二次电切结合吉西他滨膀胱灌注化疗治疗肌层浸润性膀胱癌[J]. 中国临床研究, 2018, 31(9): 1215-1219. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGCK201809016.htm
    [11]
    KIM M J, KIM Y S, OH S Y, et al. Retrospective analysis of palliative chemotherapy for the patients with bladder adenocarcinoma: Korean Cancer Study Group Genitourinary and Gynecology Cancer Committee[J]. Korean J Intern Med, 2018, 33(2): 383-390. doi: 10.3904/kjim.2015.162
    [12]
    TSIRONIS G, BAMIAS A. Treating bladder adenocarcinoma[J]. Transl Androl Urol, 2018, 7(Suppl 6): S699-S701.
    [13]
    翟天元, 罗彬杰, 贾占奎, 等. 53例膀胱腺癌的临床特征及预后相关因素分析[J]. 实用医学杂志, 2018, 34(14): 2393-2397. doi: 10.3969/j.issn.1006-5725.2018.14.028
    [14]
    NATALE C, LEINWAND Z G, CHIANG J, et al. Reviewing the demographic, prognostic, and treatment factors of primary adenocarcinoma of the bladder: a seer population-based study[J]. Clin Genitourin Cancer, 2019, 17(5): 380-388. doi: 10.1016/j.clgc.2019.06.010
    [15]
    JIN D, QIU S, JIN K, et al. Signet-Ring cell carcinoma as an independent prognostic factor for patients with urinary bladder cancer: a population-based study[J]. Front Oncol, 2020, 10: 653. doi: 10.3389/fonc.2020.00653
    [16]
    ZHOU Z, KINSLOW C J, WANG P, et al. Clear cell adenocarcinoma of the urinary bladder is a glycogen-rich tumor with poorer prognosis[J]. Clin Med, 2020, 9(1): 138. http://www.researchgate.net/publication/338379928_Clear_Cell_Adenocarcinoma_of_the_Urinary_Bladder_Is_a_Glycogen-Rich_Tumor_with_Poorer_Prognosis
    [17]
    WANG J W, WU Y, HE W Y, et al. Nomogram for predicting overall survival of patients with bladder cancer: A population-based study[J]. Int J Biol Markers, 2020, 35(2): 29-39. doi: 10.1177/1724600820907605
    [18]
    CUMBERBATCH M G K, JUBBER I, BLACK P C, et al. Epidemiology of bladder cancer: a systematic review and contemporary update of risk factors in 2018[J]. Eur Urol, 2018, 74(6): 784-795. doi: 10.1016/j.eururo.2018.09.001
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(2)  / Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (174) PDF downloads(6) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return