Volume 19 Issue 5
May  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 719-722
WU Yong, YU Ting, PENG Min, SHI Liu-fen, YU Gui-fang, YUAN Xiao-chen, GONG Kai-zheng, XU Min-zhi. Application of non-invasive impedance cardiography with transthoracic impedance cardiography in the treatment of refractory hypertension[J]. Chinese Journal of General Practice, 2021, 19(5): 719-722. doi: 10.16766/j.cnki.issn.1674-4152.001900
Citation: WU Yong, YU Ting, PENG Min, SHI Liu-fen, YU Gui-fang, YUAN Xiao-chen, GONG Kai-zheng, XU Min-zhi. Application of non-invasive impedance cardiography with transthoracic impedance cardiography in the treatment of refractory hypertension[J]. Chinese Journal of General Practice, 2021, 19(5): 719-722. doi: 10.16766/j.cnki.issn.1674-4152.001900
shu

Application of non-invasive impedance cardiography with transthoracic impedance cardiography in the treatment of refractory hypertension

doi: 10.16766/j.cnki.issn.1674-4152.001900

  • Department of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225001, China

Funds:

 81970225

 Z2017020

  • Received Date: 2020-11-26
    Available Online: 2022-02-16
    Abstract
  •   Objective  To explore the effectiveness of non-invasive hemodynamic monitoring with transthoracic impedance cardiography (ICG) to guide the antihypertensive treatment of patients with refractory hypertension (RH).   Methods  From November 2018 to October 2019, 120 patients diagnosed with RH (outpatients and inpatients) of the Affiliated Hospital of Yangzhou University were selected. According to the treatments they were assigned into different groups, the control group (n=60) was given routine treatment, and the study group (n=60) was given the treatment guided by the non-invasive hemodynamic monitoring with ICG. The treatment was followed up for a year. The blood pressure control level and hemodynamic indices including heart rate (HR), acceleration of cardiac function index (ACI), peripheral vascular resistance (systemic vascular resistance, SVR) and pleural fluid composition (thoracic fluid content, TFC) of the two groups were compared. The levels of cardiac function indexes and the incidence of cardiovascular and cerebrovascular events were also compared.   Results  After the treatment, the 24 h average systolic and diastolic blood pressure of the two groups were improved, and the systolic blood pressure [(129.50±7.41) mm Hg vs.(153.69±6.22) mm Hg] and diastolic blood pressure [(80.21±5.20) mm Hg of the study group was lower than that of the control group (98.62±6.11) mm Hg, P < 0.05]. The hemodynamic levels of the two groups were improved, the levels of HR, TFC and SVR in the study group were lower than those in the control group and the ACI level was higher than that in the control group (all P < 0.05). The cardiac function of the two groups was improved, the left ventricular ejection fraction (LVEF) level of the study group was higher than that of the control group and the level of left ventricular end-systolic dimension (LVESD) and left ventricular end-diastolic dimension (LVEDD) was lower than that of the control group (all P < 0.05). The incidence of cardiovascular and cerebrovascular events in the study group was lower than that in the control group(6.7% vs. 21.7%, P < 0.05).   Conclusion  The application of non-invasive hemodynamic monitoring with Transthoracic ICG to the adjuvant treatment of RH patients can effectively guide RH antihypertensive therapy, reduce blood pressure and hemodynamic levels and is more conducive to the improvement of cardiac function. It can also reduce the occurrence of cardiovascular and cerebrovascular diseases.

     

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