Volume 19 Issue 5
May  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 760-762,793
ZHANG Li-li, ZHANG Dong-mei, XIE Chang-hao. Clinical characteristics, treatment and follow-up analysis of newly diagnosed systemic lupus erythematosus associated thrombocytopenia[J]. Chinese Journal of General Practice, 2021, 19(5): 760-762,793. doi: 10.16766/j.cnki.issn.1674-4152.001910
Citation: ZHANG Li-li, ZHANG Dong-mei, XIE Chang-hao. Clinical characteristics, treatment and follow-up analysis of newly diagnosed systemic lupus erythematosus associated thrombocytopenia[J]. Chinese Journal of General Practice, 2021, 19(5): 760-762,793. doi: 10.16766/j.cnki.issn.1674-4152.001910
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Clinical characteristics, treatment and follow-up analysis of newly diagnosed systemic lupus erythematosus associated thrombocytopenia

doi: 10.16766/j.cnki.issn.1674-4152.001910

  • Department of Rheumatology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0319

 1608085MH215

  • Received Date: 2020-09-07
    Available Online: 2022-02-16
    Abstract
  •   Objective  To analyse the clinical features, treatment and platelet (PLT) count recovery of newly diagnosed systemic lupus erythematosus (SLE) associated thrombocytopenia (TP).  Methods  A total of 309 newly diagnosed SLE patients hospitalised in the Department of Rheumatology and Immunology of the First Affiliated Hospital of Bengbu Medical College from April 2012 to December 2018 were reviewed. According to PLT count, the patients were divided into TP group and non-TP group. The clinical manifestations and laboratory indexes between the two groups were analysed by t test, χ2 test and Mann-Whiney U test. The statistically significant indexes were selected for multivariate logistic analysis. The treatment and PLT count recovery of TP group were further analysed.  Results  The incidence of TP was 26.9% among 309 patients with newly diagnosed SLE. The incidences of lupus nephritis, leukopenia, anaemia and positive anti-SSB antibody in the TP group were higher than those in the non-TP group. The incidence of arthritis and the level of complement C3 in the TP group were lower than those in the non-TP group. The SLEDAI score in the TP group was higher than that in the non-TP group. Multivariate logistic analysis showed that anaemia was a risk factor for TP and arthritis was a protective factor for TP. The in-hospital remission rate of TP was 77.2% (61/79).  Conclusion  TP is one of the common manifestations of haematological damage in patients with newly diagnosed SLE, which is often accompanied by anaemia and lupus nephritis. Most of the patients respond well to treatment and have a high remission rate in hospital.

     

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