Volume 19 Issue 5
May  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 763-766
WANG Geng-ming, ZHOU Yan, SUN Qian, DING Jian-ming, ZHOU Shi-xiang, CHEN Man, HAN Yue-feng. Prognostic value of pretreatment neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with locally advanced hypopharyngeal cancer treated with radiation[J]. Chinese Journal of General Practice, 2021, 19(5): 763-766. doi: 10.16766/j.cnki.issn.1674-4152.001911
Citation: WANG Geng-ming, ZHOU Yan, SUN Qian, DING Jian-ming, ZHOU Shi-xiang, CHEN Man, HAN Yue-feng. Prognostic value of pretreatment neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with locally advanced hypopharyngeal cancer treated with radiation[J]. Chinese Journal of General Practice, 2021, 19(5): 763-766. doi: 10.16766/j.cnki.issn.1674-4152.001911
shu

Prognostic value of pretreatment neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with locally advanced hypopharyngeal cancer treated with radiation

doi: 10.16766/j.cnki.issn.1674-4152.001911
  • 1.

    Department of Radiotherapy, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0400

 卫科教秘[2018]291号

  • Received Date: 2020-08-28
    Available Online: 2022-02-16
    Abstract
  •   Objective  To evaluate retrospectively the prognostic value of pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with locally advanced hypopharyngeal cancer treated with radiotherapy.  Methods  Twenty-seven patients who received radiotherapy alone, sequential chemoradiotherapy or concurrent chemoradiotherapy for locally advanced hypopharyngeal cancer in our hospital from February 2017 to December 2018 were retrospectively analysed. The patients were divided into two groups: high (NLR group/low NLR group and high PLR group/low PLR groups. Appropriate cut-off points were determined via the receiver operating characteristic curve(ROC) method. The survival curve was established via the Kaplan-Meier method. The survival of the two groups was compared via log-rank test. Multivariate Cox regression analysis was conducted by.  Results  Among the 27 patients, 10 patients were still alive. The median follow-up time was 34 months, and the median survival time was 21 months. The best cut-off value of NLR and PLR before radiotherapy was 2.30 and 131.46, respectively. The 2-year overall survival rates of patients in the high NLR and the low NLR groups before radiotherapy were 18.8% and 45.5%, respectively (P=0.006). The 2-year overall survival rates of patients in the high PLR and the low PLR groups before radiotherapy were 18.8% and 45.5%, respectively (P=0.040). Log rank single-factor analysis revealed that tumour clinical stage, treatment and NLR/PLR ratio before radiotherapy were related to the overall survival of patients (all P < 0.05). Multivariate analysis showed that tumour clinical stage and treatment were independent factors affecting the overall survival of patients.  Conclusion  An increase in NLR/PLR ratio before radiotherapy may affect the prognosis of patients with hypopharyngeal cancer. However, the sample size of this study was small. Thus, further research is needed.

     

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