Volume 19 Issue 5
May  2021
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 775-777,785
YAO Wei-wei, DONG Qing-hua. Observation on the clinical effect of recombinant human interleukin-11 combined with Kangfuxin liquid in the treatment of radiation-induced oral mucositis[J]. Chinese Journal of General Practice, 2021, 19(5): 775-777,785. doi: 10.16766/j.cnki.issn.1674-4152.001914
Citation: YAO Wei-wei, DONG Qing-hua. Observation on the clinical effect of recombinant human interleukin-11 combined with Kangfuxin liquid in the treatment of radiation-induced oral mucositis[J]. Chinese Journal of General Practice, 2021, 19(5): 775-777,785. doi: 10.16766/j.cnki.issn.1674-4152.001914
shu

Observation on the clinical effect of recombinant human interleukin-11 combined with Kangfuxin liquid in the treatment of radiation-induced oral mucositis

doi: 10.16766/j.cnki.issn.1674-4152.001914
  • 1.

    Department of Stomatology, Changxing District of the Second Affiliated Hospital of Zhejiang University, Huzhou, Zhejiang 313100, China

Funds:

 2019ZD010

  • Received Date: 2020-11-02
    Available Online: 2022-02-16
    Abstract
  •   Objective  To observe the clinical effect of recombinant human interleukin-11 (rhIL-11) aerosol inhalation combined with Kangfuxin liquid gargle in the treatment of radiation-induced oral mucositis.  Methods  A total of 110 patients with head and neck tumour radiotherapy in Changxing County People' s Hospital from July 2016 to July 2020 were randomly divided into control group (n=55) and study group (n=55). The patients in the control group were treated with oral gargle of triple drug solution, whereas the patients in the study group were additionally given rhIL-11 aerosol inhalation combined with Kangfuxin liquid oral gargle. The degree of oral mucosal reaction was compared between the two groups at the end of radiotherapy. The degree of oral mucosal pain was evaluated during radiotherapy. The time of oral mucosal reaction above grade 3 was recorded. The clinical efficacy of radiation-induced oral mucositis was analysed.  Results  The proportion of patients with severe radiation-induced oral mucosal reaction at the end of radiotherapy in the study group (14.54%) was significantly lower than that in the control group (36.36%, χ2=6.899, P=0.009). The NRS scores of oropharyngeal pain in the study group at 2 weeks, 4 weeks and at the end of radiotherapy (1.17±0.32, 3.28±0.74 and 4.41±0.83) were significantly lower than those in the control group (1.69±0.43, 4.35±0.81 and 6.03±0.92, t=4.196-6.235, all P < 0.001). The time of severe radiation-induced oral mucosal reaction in the study group (8 patients) was (5.47±0.79) weeks, which was significantly later than that of the control group [20 patients, (4.51±0.62) weeks, t=5.273, P < 0.001]. The overall effective rate of the study group (96.36%) was significantly higher than that of the control group (81.82%, χ2=5.986, P=0.014).  Conclusion  Recombinant human interleukin-11 aerosol inhalation combined with Kangfuxin Liquid gargle can effectively reduce the degree of oral mucosa injury in patients with head and neck cancer during radiotherapy, relieve the pain response, alleviate the progress of the disease and improve the clinical efficacy of radiation-induced oral mucositis, and thus, this treatment is worthy of clinical application.

     

    • FullText(HTML)
  • loading
    • References(16)
  • [1]
    陈军. 白介素-11在放射性口腔粘膜炎患者治疗中的应用[J]. 全科口腔医学电子杂志, 2018, 5(20): 46-47. doi: 10.3969/j.issn.2095-7882.2018.20.027
    [2]
    李娟, 孙鹏. 复方碳酸氢钠液治疗放射性口腔粘膜炎的临床研究[J]. 全科口腔医学电子杂志, 2018, 5(20): 73, 78. https://www.cnki.com.cn/Article/CJFDTOTAL-QKKQ201820043.htm
    [3]
    刘尚贤, 张瑜, 郑茁, 等. 人粒细胞巨噬细胞刺激因子含漱预防放射性口腔黏膜炎的疗效观察[J]. 中国医药科学, 2020, 10(14): 72-74, 108. doi: 10.3969/j.issn.2095-0616.2020.14.020
    [4]
    沈永菊, 李淑华, 段诗苗, 等. 综合护理干预对头颈部肿瘤患者放疗致口腔黏膜反应的效果观察[J]. 中华全科医学, 2014, 12(10): 1674-1675, 1677. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201410057.htm
    [5]
    黄文强, 陈艳华. 环氧化酶-2及其抑制剂与头颈部肿瘤免疫治疗研究进展分析[J]. 大家健康(中旬版), 2017, 11(2): 93-95.
    [6]
    杨晓梅, 金建华, 吴建亭, 等. 头颈部肿瘤精确放射治疗个体化固定技术临床应用[J]. 生物医学工程与临床, 2019, 23(4): 452-455. https://www.cnki.com.cn/Article/CJFDTOTAL-SGLC201904017.htm
    [7]
    宋利. 头颈部肿瘤患者放射治疗期间的舒适水平与危险因素分析[J]. 黑龙江医药科学, 2019, 42(2): 87-88. doi: 10.3969/j.issn.1008-0104.2019.02.039
    [8]
    潘琦津, 龚建忠, 韦燕. 头颈部肿瘤患者放射性口咽炎防治的研究进展[J]. 医学综述, 2018, 24(18): 3592-3597. doi: 10.3969/j.issn.1006-2084.2018.18.011
    [9]
    牟进, 范凤霞, 屈云. 头颈部恶性肿瘤患者放疗后吞咽困难的康复治疗研究进展[J]. 肿瘤预防与治疗, 2020, 33(3): 275-280. doi: 10.3969/j.issn.1674-0904.2020.03.013
    [10]
    王玉斌, 林玉成, 王建化, 等. 勾画颌下腺在鼻咽癌三维调强适形放疗中对患者放疗后口干和生活质量的影响[J]. 中华全科医学, 2018, 16(12): 1992-1995, 2009. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201812012.htm
    [11]
    谢靖, 盛沛, 李博, 等. 放射性口腔黏膜炎的发病机制及中西医防治研究进展[J]. 南京中医药大学学报, 2019, 35(3): 338-343. https://www.cnki.com.cn/Article/CJFDTOTAL-NJZY201903021.htm
    [12]
    尹燕, 张静平. 放射性口腔黏膜炎影响因素研究进展[J]. 中华放射肿瘤学杂志, 2020, 29(9): 799-803. doi: 10.3760/cma.j.cn113030-20200128-00033
    [13]
    陈敏, 陈芳, 田昕, 等. 康复新液在头颈部肿瘤放疗患者中缓解放射性口腔黏膜炎的作用[J]. 中国保健营养, 2018, 28(17): 8-9. doi: 10.3969/j.issn.1004-7484.2018.17.008
    [14]
    陈宇杰, 李雪青, 石志敏. 复方黄柏液联合康复新液治疗放射性直肠损伤的随机对照研究[J]. 成都中医药大学学报, 2018, 41(3): 67-70. https://www.cnki.com.cn/Article/CJFDTOTAL-CDZY201803017.htm
    [15]
    王冬平, 崔晓慧, 李影. 白细胞介素-11雾化吸入在放射性口腔黏膜炎患者中的作用探讨[J]. 中国现代药物应用, 2019, 13(8): 114-116. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY201908066.htm
    [16]
    肖静, 郑细优, 万丽, 等. 康复新液联合重组人粒细胞刺激因子注射液治疗放射性黏膜炎疗效分析[J]. 上海医药, 2020, 41(6): 34-36. https://www.cnki.com.cn/Article/CJFDTOTAL-SYIY202006012.htm
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (262) PDF downloads(5) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return