Volume 19 Issue 5
May  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(5): 789-793
SHAO Gang, QI Rui-hua, ZANG Hong-cheng, YE Xu-qin. Effect of different administration methods of dexmedetomidine on perioperative indexes in elderly patients with colorectal cancer[J]. Chinese Journal of General Practice, 2021, 19(5): 789-793. doi: 10.16766/j.cnki.issn.1674-4152.001918
Citation: SHAO Gang, QI Rui-hua, ZANG Hong-cheng, YE Xu-qin. Effect of different administration methods of dexmedetomidine on perioperative indexes in elderly patients with colorectal cancer[J]. Chinese Journal of General Practice, 2021, 19(5): 789-793. doi: 10.16766/j.cnki.issn.1674-4152.001918
shu

Effect of different administration methods of dexmedetomidine on perioperative indexes in elderly patients with colorectal cancer

doi: 10.16766/j.cnki.issn.1674-4152.001918
  • 1.

    Department of Anesthesiology, the First People's Hospital of Fuyang District, Hangzhou, Zhejiang 311400, China

Funds:

 2018KY659

  • Received Date: 2020-05-08
    Available Online: 2022-02-16
    Abstract
  •   Objective  To investigate and analyze the effect of different administration methods of dexmedetomidine combined with transverse abdominal plane (TAP) block on the recovery and immune function of elderly patients after radical resection of colorectal cancer.  Methods  Total 95 elderly patients with colorectal cancer undergoing radical surgery admitted to the First People's Hospital of Fuyang District from June 2018 to June 2019 were divided into observation group (48 cases) and control group (47 cases) according to the random number table method. The patients in the observation group were given dexmedetomidine in TAP block, and the patients in the control group were given intravenous load before anesthesia induction. The general data, hemodynamic parameters (HR, MAP, SpO2), SAS score (Riker sedation and agitation score), recovery during recovery, postoperative pain score, and immune index (CD4+, CD8+, CD4+/CD8+) were observed.  Results  The HR and MAP of the two groups at extubation were significantly higher than those at the end of operation (all P < 0.05). The restlessness scores at eye opening, extubation and 30 min after extubation in the observation group were significantly lower than those in the control group (all P < 0.05). The recovery time of spontaneous breathing, eye opening time and extubation time in the observation group were significantly lower than those in the control group (all P < 0.05). The VAS scores of the two groups on the 1st and 3rd day after operation were 6. The VAS score of the observation group were significantly lower than that of the control group at 1 d and 3 d after operation (all P < 0.05). The levels of CD4+, CD8+, CD4+/CD8+ in the observation group were significantly higher than those in the control group (all P < 0.05).  Conclusion  Dexmedetomidine combined with TAP block is more effective than intravenous drug combined with TAP block in shortening the recovery time and improving the postoperative immune function of patients, which is worthy of clinical promotion.

     

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