Volume 19 Issue 6
Jun.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(6): 898-900,907
LIU Li-jun, LIU Xue-yun, WU Xiao-san, QIU Ju, WU Tong, HAN Yong-sheng, WANG Xun. Influencing factors of hemorrhagic transformation in non-thrombolytic patients after acute large area cerebral infarction[J]. Chinese Journal of General Practice, 2021, 19(6): 898-900,907. doi: 10.16766/j.cnki.issn.1674-4152.001944
Citation: LIU Li-jun, LIU Xue-yun, WU Xiao-san, QIU Ju, WU Tong, HAN Yong-sheng, WANG Xun. Influencing factors of hemorrhagic transformation in non-thrombolytic patients after acute large area cerebral infarction[J]. Chinese Journal of General Practice, 2021, 19(6): 898-900,907. doi: 10.16766/j.cnki.issn.1674-4152.001944
shu

Influencing factors of hemorrhagic transformation in non-thrombolytic patients after acute large area cerebral infarction

doi: 10.16766/j.cnki.issn.1674-4152.001944
  • 1.

    Department of Neurology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, China

Funds:

 81774425

  • Received Date: 2020-11-25
    Available Online: 2022-02-16
    Abstract
  •   Objective  This study was aimed to explore the influencing factors of hemorrhagic transformation (HT) in non-thrombolytic patients with acute massive cerebral infarction by analyzing the differences in factors between the massive cerebral infarction hemorrhage transformation group and the non-hemorrhage transformation group, and the basis for prognosis judgment was provided.  Methods  Count patients with acute massive cerebral infarctions and did not receive thrombolysis in the Department of Neurology of the Second Affiliated Hospital of Anhui Medical University from January 2018 to December 2019, we collected general information of patients, risk factors of stroke, the levels of blood calcium and magnesium on admission, and analyze the difference between the hemorrhage transformation group and the non-hemorrhage transformation group.  Results  A total of 114 patients were enrolled in this study, of which 88 were in the group without hemorrhage transformation and 26 were in the group with hemorrhage transformation. Univariate analysis showed that the patients with hemorrhage transformation combined with atrial fibrillation were significantly more than those without hemorrhage transformation (P < 0.05), and the levels of low-density lipoprotein cholesterol, blood calcium, and magnesium were also significantly lower than those in the hemorrhage transformation group (all P < 0.05). Multivariate logistic analysis showed that atrial fibrillation was positively correlated with hemorrhagic transformation in non-thrombolytic patients with massive cerebral infarction (OR=4.731, 95% CI: 1.594-14.044, P=0.005), and There was an negative correlation between serum magnesium and hemorrhagic transformation in non-thrombolytic patients with cerebral infarction (OR=0.000, 95% CI: 0.000-0.095, P=0.006).  Conclusion  Atrial fibrillation and hypomagnesemia may be independent risk factors for hemorrhagic transformation of acute massive cerebral infarction.

     

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