Volume 19 Issue 6
Jun.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(6): 908-912
WANG Jing-yue, SUN Bo, PENG Yan-bo, CHAI Hai-xia, FAN Hai-yan, BIAN Zhe. Correlation between stress hyperglycaemia ratio and early cognitive dysfunction in patients with anterior circulation perforator arteriosclerotic cerebral infarction[J]. Chinese Journal of General Practice, 2021, 19(6): 908-912. doi: 10.16766/j.cnki.issn.1674-4152.001947
Citation: WANG Jing-yue, SUN Bo, PENG Yan-bo, CHAI Hai-xia, FAN Hai-yan, BIAN Zhe. Correlation between stress hyperglycaemia ratio and early cognitive dysfunction in patients with anterior circulation perforator arteriosclerotic cerebral infarction[J]. Chinese Journal of General Practice, 2021, 19(6): 908-912. doi: 10.16766/j.cnki.issn.1674-4152.001947
shu

Correlation between stress hyperglycaemia ratio and early cognitive dysfunction in patients with anterior circulation perforator arteriosclerotic cerebral infarction

doi: 10.16766/j.cnki.issn.1674-4152.001947
  • 1.

    Department of Neurology, North China University of Science and Technology Hospital, Tangshan, Hebei 063000, China

Funds:

 20201238

  • Received Date: 2020-07-02
    Available Online: 2022-02-16
    Abstract
  •   Objective  To discuss the effects of high blood sugar stress ratio on early cognitive dysfunction of patients with Anterior circulation perforator arteriosclerotic cerebral infarction.  Methods  From December 2014 to December 2019, patients with anterior circulation perforator arteriosclerotic cerebral infarction who were hospitalised in neurology department of Affiliated Hospital of North China University of Science and Technology were selected as the observation objects. According to the 90-day Montreal Cognitive Assessment (MoCA) score, all the patients were divided into two groups: cognitive dysfunction group(145 cases) and normal cognitive function group(187 cases). Data were collected to analyse the correlation between stress hyperglycaemia rate (SHR) and 90 day MoCA and A Mini-Mental State Examination (MMSE) scores. Receiver Operator Characteristic (ROC) curve was used to evaluate the effectiveness of SHR-related indicators in predicting cognitive impairment.  Results  In this study, the incidence of early cognitive impairment was 43.67%. The single-factor analysis showed that the differences in age, hypertension, diabetes history, education level, The NIH Stroke Scale (NIHSS) score, random blood sugar and SHR in the two groups were statistically significant. The Multivariate logistic regression analysis showed that age (OR=1.144, 95%CI: 1.097-1.193, P < 0.001), NIHSS score (OR=2.455, 95%CI: 1.254-4.804, P=0.009), SHR (OR=2.087, 95%CI: 1.053-4.137, P=0.035)and random blood glucose (OR=1.008, 95%CI: 1.001-2.012, P=0.047)were independent risk factors for early cognitive impairment after anterior circulation perforator arteriosclerotic cerebral infarction. Correlation analysis showed a negative correlation between SHR and MoCA and MMSE scores for 90 days. The area under ROC curve of SHR and admission random blood glucose in predicting the early cognitive impairment of patients with anterior circulation perforator arteriosclerotic cerebral infarction was 0.795 and 0.626, respectively, and the difference in area under the two sets of ROC curves was statistically significant.  Conclusion  SHR is an independent risk factor of cognitive dysfunction in the early stage of patients with anterior circulation perforator arteriosclerotic cerebral infarction. SHR can be used as an important reference index to predict cognitive prognosis.

     

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