Volume 19 Issue 6
Jun.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(6): 947-949
YAN Xian-ting, HUANG Qing-dong, TANG Ting-yu, WANG Yan-hong, LU Xiao-ling. Correlation of serum inflammatory factors and pulmonary function with the severity of OSAHS[J]. Chinese Journal of General Practice, 2021, 19(6): 947-949. doi: 10.16766/j.cnki.issn.1674-4152.001957
Citation: YAN Xian-ting, HUANG Qing-dong, TANG Ting-yu, WANG Yan-hong, LU Xiao-ling. Correlation of serum inflammatory factors and pulmonary function with the severity of OSAHS[J]. Chinese Journal of General Practice, 2021, 19(6): 947-949. doi: 10.16766/j.cnki.issn.1674-4152.001957
shu

Correlation of serum inflammatory factors and pulmonary function with the severity of OSAHS

doi: 10.16766/j.cnki.issn.1674-4152.001957

  • Department of Respiratory Medicine, Zhejiang Hospital, Hangzhou, Zhejiang 310030, China

Funds:

 LGF19H010007

  • Received Date: 2020-10-13
    Available Online: 2022-02-16
    Abstract
  •   Objective  To investigate the correlation between inflammatory factors and lung function and the severity of obstructive sleep apnea-hypopnea syndrome (OSAHS) to provide reference for clinical treatment.  Methods  The 179 OSAHS patients from Zhejiang Hospital from March 2018 to March 2020 were selected; 80 patients with healthy physical examination during the same period were selected as the control group. The levels of IL-6, IL-18 and TNF-α were measured by enzyme-linked immunosorbent assay, the tidal volume (VT), maximum vital capacity (VCmax), forced vital capacity (FVC) and forced expiratory volume (FEV1) were measured by pulmonary function instrument, and the sleep quality was evaluated by Pittsburgh sleep quality index (PSQI).  Results  The levels of serum IL-6, IL-18 and TNF-α in mild to moderate group [(28.21±5.12)pg/mL, (22.35±4.12)ng/L and (187.46±37.23)ng/L] and severe group [(45.17±6.71)pg/mL, (42.10±5.62)ng/L and (297.42±30.19) g/L] were higher than those in control group [(11.82±3.27)pg/mL, (9.65±2.19) ng/L and (108.91±25.26)ng/L, P < 0.05]. The VT, VCmax, FVC and FEV1 in mild to moderate group and severe group lower than those in control group (all P < 0.05). IL-6, IL-18 and TNF-α were positively correlated with severe OSAHS, while VT, VCmax, FVC and FEV1 were negatively correlated with severe OSAHS.  Conclusion  OSAHS patients have inflammatory reaction, decreased pulmonary function, and the more obvious the inflammatory reaction is, the more obvious the pulmonary function.

     

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