Volume 19 Issue 6
Jun.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(6): 950-953
WANG Xin, WU Qiao-min, TANG Yu-xiao, ZHANG Mei-fang, CHEN Jie-wen. Mechanism of Portulaca oleracea L. in the treatment of non-alcoholic fatty liver disease based on data analysis[J]. Chinese Journal of General Practice, 2021, 19(6): 950-953. doi: 10.16766/j.cnki.issn.1674-4152.001958
Citation: WANG Xin, WU Qiao-min, TANG Yu-xiao, ZHANG Mei-fang, CHEN Jie-wen. Mechanism of Portulaca oleracea L. in the treatment of non-alcoholic fatty liver disease based on data analysis[J]. Chinese Journal of General Practice, 2021, 19(6): 950-953. doi: 10.16766/j.cnki.issn.1674-4152.001958
shu

Mechanism of Portulaca oleracea L. in the treatment of non-alcoholic fatty liver disease based on data analysis

doi: 10.16766/j.cnki.issn.1674-4152.001958
  • 1.

    Department of Clinical Nutrition, the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China

Funds:

 81903306

  • Received Date: 2020-11-11
    Available Online: 2022-02-16
    Abstract
  •   Objective  To explore the molecular mechanism of Portulaca oleracea L. in the treatment of non-alcoholic fatty liver (NAFLD).  Methods  With the use of the TCMSP and Drug Bank and Uniprot database, the effective activity of Portulaca oleracea L. was screened out ingredients and their potential targets. The Drug bank, OMMI and GeneCards databases were used in identifying gene targets related to NAFLD and intersection targets. Finally, the DAVID database was used in conducting KEGG and GO enrichment analyses for determining the potential signal pathways of Portulaca oleracea L. for NAFLD treatment.  Results  Portulaca oleracea L. had 10 effective active ingredients, of which quercetin, kaempferol, luteolin, β-sitosterol and β-carotene were the main active ingredients. A total of 85 key targets were identified after matching with NAFLD gene targets, and tumor necrosis factor (TNF), cysteine aspartic protease, Ser/Thr protein kinase and inflammatory chemokines were found to be important targets. DAVID enrichment analysis showed that GO functional analysis were mainly involved in inflammation (P < 0.001), cell hypoxia (P < 0.001), and apoptosis (P < 0.001), identical protein binding (P < 0.001), protein polymerisation activity (P < 0.001) and cytokine activity (P < 0.001). KEGG enrichment analysis mainly related to TNF (P < 0.001), apoptosis (P < 0.001), TLR (P < 0.001) and NF-κB signal pathway (P < 0.001).  Conclusion  This study preliminarily explores the potential targets and related signal pathways of Portulaca oleracea L. in NAFLD treatment and provides a theoretical basis for further revealing mechanisms for developing the functional food of Portulaca oleracea L.

     

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