Volume 19 Issue 6
Jun.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(6): 1013-1016,1034
LI Li-yang, XU Peng, WANG Bei-di, GAO Shuang, GUO Yu, KUANG Ye. Research progress of MicroRNA-429 in gynecological malignant tumors[J]. Chinese Journal of General Practice, 2021, 19(6): 1013-1016,1034. doi: 10.16766/j.cnki.issn.1674-4152.001973
Citation: LI Li-yang, XU Peng, WANG Bei-di, GAO Shuang, GUO Yu, KUANG Ye. Research progress of MicroRNA-429 in gynecological malignant tumors[J]. Chinese Journal of General Practice, 2021, 19(6): 1013-1016,1034. doi: 10.16766/j.cnki.issn.1674-4152.001973
shu

Research progress of MicroRNA-429 in gynecological malignant tumors

doi: 10.16766/j.cnki.issn.1674-4152.001973

  • Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China

Funds:

 320675018061

  • Received Date: 2020-08-08
    Available Online: 2022-02-16
    Abstract
  • Gynecological malignant tumors is a problem that threatens women's health, of which early diagnosis and treatment are of great significance to the prognosis. MicroRNA (miRNA) is a small non-coding RNA involved in post-transcriptional regulation of cells, which plays a key role in the normal physiological processes of cells and the development of tumors. MicroRNA-429 (miR-429) can inhibit the expression of zinc E-box-binding homobox 1 (ZEB1) and ZEB2, which affects tumor progression and metastasis, and regulates Slug Gene expression in order to affects the expression of E-cadherin and Snail protein, and regulates the epithelial-mesenchymal transition (EMT) in tumors, which affects tumor migration, invasion, prognosis, and drug sensitivity. MiR-429 plays a tumor-promoting role in ovarian cancer and is not conducive to the prognosis, but its low expression is associated with low patient survival rates, and the differential expression of miR-429 was found in the ascites of ovarian cancer patients, which has potential clinical diagnostic significance. It plays a role in tumor suppression in cervical cancer role; plays a tumor-promoting role in endometrial cancer, and may have potential diagnostic value in endometrial cancer.The related literature on miR-429 and it's role in gynecological malignancies is reviewed, combined with tumor occurrence, invasion and other factors to discuss, comprehensively analyze the significance of miR-429 in gynecological malignancies, and for the further study significance in clinical application provides reference.

     

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