Volume 19 Issue 8
Aug.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(8): 1277-1279
WANG Shuanhu, LIU Yakui, SHI Yi, GUAN Jiajia, LIU Mulin. Analysis on risk factors of anastomotic leakage after anterior resection for rectal cancer[J]. Chinese Journal of General Practice, 2021, 19(8): 1277-1279. doi: 10.16766/j.cnki.issn.1674-4152.002039
Citation: WANG Shuanhu, LIU Yakui, SHI Yi, GUAN Jiajia, LIU Mulin. Analysis on risk factors of anastomotic leakage after anterior resection for rectal cancer[J]. Chinese Journal of General Practice, 2021, 19(8): 1277-1279. doi: 10.16766/j.cnki.issn.1674-4152.002039
shu

Analysis on risk factors of anastomotic leakage after anterior resection for rectal cancer

doi: 10.16766/j.cnki.issn.1674-4152.002039

  • Department of Gastrointestinal Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2017A219

 BYKC201909

  • Received Date: 2020-09-03
    Available Online: 2022-02-16
    Abstract
  •   Objective  With the application of total mesorectal excision (TME), the long-term effect of rectal cancer has been greatly improved. However, the incidence of postoperative anastomotic leakage of rectal cancer is not significantly reduced, so it is very important to explore the risk factors of postoperative anastomotic leakage of rectal cancer.  Methods  A retrospective case-control study was conducted to analyze the cases of anterior resection for rectal cancer in Department of Gastrointestinal Surgery, of the First Affiliated Hospital of Bengbu Medical College from January 2017 to December 2019. According to the occurrence of anastomotic leakage, the patients were divided into anastomotic leakage group (38 cases) and non-anastomotic leakage group (395 cases). Univariate and multivariate analysis were carried out to explore the risk factors of anastomotic leakage.  Results  Anastomotic leakage occurred in 38 patients (9.62%) of 395 patients with rectal cancer who underwent anterior resection. Chi-square test showed that gender (P=0.005) and the number of distal rectal cut closure (P=0.031) were significantly associated with anastomotic leakage. Multivariate logistic regression analysis revealed that male (OR=3.145, 95% CI: 1.344-7.356, P=0.008) and more than 2 staples of distal rectal cut closure (OR=2.083, 95% CI: 1.026-4.229, P=0.042) were independent risk factors for anastomotic leakage.  Conclusion  The incidence of anastomotic leakage in patients undergoing anterior resection is 9.62%. The high risk factors for anastomotic leakage are male and more than 2 staples of distal rectal cut closure. In order to reduce the occurrence of anastomotic leakage, it is helpful to reduce use frequency of staples of distal rectal cut closure.

     

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