Volume 19 Issue 8
Aug.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(8): 1322-1325,1429
SONG Fei-fei, ZHANG Lan. Comparison of LISA technique and INSURE technique in the treatment of respiratory distress syndrome in premature infants[J]. Chinese Journal of General Practice, 2021, 19(8): 1322-1325,1429. doi: 10.16766/j.cnki.issn.1674-4152.002051
Citation: SONG Fei-fei, ZHANG Lan. Comparison of LISA technique and INSURE technique in the treatment of respiratory distress syndrome in premature infants[J]. Chinese Journal of General Practice, 2021, 19(8): 1322-1325,1429. doi: 10.16766/j.cnki.issn.1674-4152.002051
shu

Comparison of LISA technique and INSURE technique in the treatment of respiratory distress syndrome in premature infants

doi: 10.16766/j.cnki.issn.1674-4152.002051

  • Department of Pediatrics, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui 230001, China

Funds:

 WA2020HK60

  • Received Date: 2021-03-11
    Available Online: 2022-02-16
    Abstract
  •   Objective  To compare the outcomes and side effects between the less invasive surfactant administration (LISA) and the intubate surfactant extubate (INSURE) method in premature infants with respiratory distress syndrome.   Methods   In the experimental group, 20 children who met the inclusion criteria were recruited from eight neonatal intensive care units in Anhui Province from August 2019 to April 2020 to complete pulmonary surfactant (PS) administration by LISA technology. In the control group, 36 children were recruited from Anhui Provincial Hospital from January 2017 to January 2020 to complete PS administration by INSURE technology. The basic information of children and mothers, arterial blood gas values before and after administration, oxygen saturation and heart rate during administration, complications and oxygen use during hospitalisation were collected and compered.   Results   The pH value of the LISA group after administration was significantly higher than that before administration (P < 0.001). The PCO2 value in the LISA group after administration was significantly lower than that before administration (P=0.005). The PO2 changes in the LISA group before and after administration were not statistically significant. The pH, PCO2 and PO2 values of the INSURE group showed no significant changes before and after administration. The LISA group tended to have a normal pH range compared with the INSURE group (P=0.009). The decrease of blood oxygen saturation during the administration was statistically significant between the two groups (P=0.041). No statistically significant difference was observed in the incidence of bronchopulmonary dysplasia (BPD), noninvasive failure rate and time of noninvasive ventilation between the two groups.   Conclusion   LISA technology can be performed in infants with spontaneous breathing, and it can significantly improve alveolar ventilation without increasing the incidence of complications such as BPD.

     

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