Volume 19 Issue 9
Sep.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(9): 1439-1441,1446
WANG Wen-bin, ZHAN Yan-qing, HAN Long, LI Yang-yang, LI Yong-sheng. Efficacy and prognosis of catheter-directed thrombolysis combined with iliac vein stenting for deep vein thrombosis[J]. Chinese Journal of General Practice, 2021, 19(9): 1439-1441,1446. doi: 10.16766/j.cnki.issn.1674-4152.002080
Citation: WANG Wen-bin, ZHAN Yan-qing, HAN Long, LI Yang-yang, LI Yong-sheng. Efficacy and prognosis of catheter-directed thrombolysis combined with iliac vein stenting for deep vein thrombosis[J]. Chinese Journal of General Practice, 2021, 19(9): 1439-1441,1446. doi: 10.16766/j.cnki.issn.1674-4152.002080
shu

Efficacy and prognosis of catheter-directed thrombolysis combined with iliac vein stenting for deep vein thrombosis

doi: 10.16766/j.cnki.issn.1674-4152.002080
  • 1.

    Department of General Surgery, the Fourth Affiliated Hospital to Anhui Medical University, Hefei, Anhui 230000, China

Funds:

 81500373

 202004j07020035

 1608085MH193

  • Received Date: 2020-08-25
    Available Online: 2022-02-15
    Abstract
  •   Objective  To compare the efficacy between catheter-directed thrombolysis combined with iliac vein stent implantation and peripheral thrombolysis in the treatment of lower extremity deep vein thrombosis with iliac vein stenosis.   Methods  A retrospective analysis was performed on patients diagnosed with deep vein thrombosis combined with iliac vein stenosis in our institution from December 2014 to December 2019. A total of 42 cases were included in this study, 15 of which underwent peripheral thrombolysis (systematic thrombolysis group) and 27 of which received catheter-directed thrombolysis combined with iliac vein stenting (catheter-directed thrombolysis group). Clinical data including complications, effective rate of thrombolysis and incidence of post-thrombotic syndrome were collected and compared between the two groups.   Results  The thrombolytic doses of the systemic thrombolysis group and catheter-directed thrombolysis group were (3.35±1.34) and (3.04±1.16) million U, respectively. Three patients in the systematic thrombolysis group and two patients in the catheter-directed thrombolysis group had complications. No significant difference was observed in the thrombolytic dose and complication rate between the two groups (all P>0.05); the effective rate of thrombolysis in the systemic thrombolytic group was 53.33%, whilst the rate was 88.89% in the catheter-directed thrombolysis group, which was higher than that in the systematic thrombolysis group (P < 0.05). The average Villalta score of the systematic thrombolysis group was 2.53 points, and that of the catheter-directed thrombolysis group was 1.77 points. The incidence of post-thrombotic syndrome was lower in the catheter-directed thrombolysis group than in the systematic thrombolysis group (P < 0.01). In addition, the VEINES-QOL/Sym scores in the systematic thrombolysis group were 35.33 and 32.67 points, whilst those in the catheter-directed thrombolysis group were 49.00 and 45.67 points. The scores were significantly higher in the catheter-directed thrombolysis group than in the systematic thrombolysis group (P < 0.01).   Conclusion  Catheter-directed thrombolysis combined with iliac vein stent has a better curative effect for patients with deep vein thrombosis of lower extremities with iliac vein stenosis.

     

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