Volume 19 Issue 9
Sep.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(9): 1451-1454, 1503
YANG Guang, XU Chen-chen, WANG Jia-wei, DING Ting-ting, LIU Li-jun, LIU Fei-fei, WU Tong, WANG Xun. Study on the correlation between serum homocysteine and blood lipid levels and white matter lesions in patients with Parkinson's disease[J]. Chinese Journal of General Practice, 2021, 19(9): 1451-1454, 1503. doi: 10.16766/j.cnki.issn.1674-4152.002083
Citation: YANG Guang, XU Chen-chen, WANG Jia-wei, DING Ting-ting, LIU Li-jun, LIU Fei-fei, WU Tong, WANG Xun. Study on the correlation between serum homocysteine and blood lipid levels and white matter lesions in patients with Parkinson's disease[J]. Chinese Journal of General Practice, 2021, 19(9): 1451-1454, 1503. doi: 10.16766/j.cnki.issn.1674-4152.002083
shu

Study on the correlation between serum homocysteine and blood lipid levels and white matter lesions in patients with Parkinson's disease

doi: 10.16766/j.cnki.issn.1674-4152.002083
  • 1.

    Department of Neurology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230000, China

Funds:

 81904086

  • Received Date: 2021-04-05
    Available Online: 2022-02-15
    Abstract
  •   Objective  To find out the risk factors of leukoencephalopathy (WML) in patients with Parkinson's disease (PD) and the correlation between homocysteine levels and WML.   Methods  From January 2015 to January 2020, 200 patients with PD who were hospitalized in the Department of Neurology of the Second Affiliated Hospital of Anhui Medical University were selected as the study group, and 110 patients with healthy physical examination during the same period were selected as the control group. Medical history and demographic data were collected. The level of biochemical indicators in each group were determined. The Fazekas classification was used to divide the study group into four groups. The differences in clinical data and biochemical indicators between the four groups were compared, and logistic regression analysis and Spearman correlation analysis were used to determine the influencing factors of PD patients with WML.   Results  The level of Hcy and the incidence and severity of WML in the study group were higher than those of the control group, and the blood lipid level was lower than that of the control group (all P < 0.05), the Hcy and WML were positively correlated (r=0.556, P < 0.001). After adjusting for demographics and confounding factors, the Hcy level was still positively correlated with the severity of WML (r=0.400, P < 0.001). The AUC of Hcy on WML in PD patients was 0.717 (95% CI: 0.673-0.861, P < 0.001); WML severity was positively correlated with PD patients' HY score and UPDRS exercise score (r=0.460, r=0.360, P < 0.001).   Conclusion  Elevated blood Hcy level may be an independent risk factor for PD patients with WML. Elevated HDL-C level is a protective factor for PD patients with WML. The Hcy may be used as a biomarker for PD patients with WML.

     

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