Effect of thymosin α 1 on T lymphocytes and TLR9 signaling pathway in patients with sepsis

LI Yuan-si; CHENG Ling; ZHANG Qi; NIE Wei-qun; LIN Yan-lin

doi:10.16766/j.cnki.issn.1674-4152.002088

Volume 19 Issue 9

Sep. 2021

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Article Navigation > Chinese Journal of General Practice > 2021 > 19(9): 1470-1473

LI Yuan-si, CHENG Ling, ZHANG Qi, NIE Wei-qun, LIN Yan-lin. Effect of thymosin α 1 on T lymphocytes and TLR9 signaling pathway in patients with sepsis[J]. Chinese Journal of General Practice, 2021, 19(9): 1470-1473. doi: 10.16766/j.cnki.issn.1674-4152.002088

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LI Yuan-si, CHENG Ling, ZHANG Qi, NIE Wei-qun, LIN Yan-lin. Effect of thymosin α 1 on T lymphocytes and TLR9 signaling pathway in patients with sepsis[J]. Chinese Journal of General Practice, 2021, 19(9): 1470-1473. doi: 10.16766/j.cnki.issn.1674-4152.002088

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Effect of thymosin α 1 on T lymphocytes and TLR9 signaling pathway in patients with sepsis

doi: 10.16766/j.cnki.issn.1674-4152.002088

LI Yuan-si¹
, CHENG Ling¹
, ZHANG Qi^{2, 3
,
,}
, NIE Wei-qun¹
, LIN Yan-lin¹

1.
Department of Intensive Medicine, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230031, China

Funds:

gxyq2019035

Received Date: 2020-09-25
Available Online: 2022-02-15

Abstract

Abstract

Objective To observe the effects of thymosin α1 on changes in indicators such as immunity in patients with sepsis, and to seek evidence-based evidence for its application in the treatment of sepsis. Methods According to the random number table, 50 patients with sepsis admitted to the ICU of the First Affiliated Hospital of Anhui University of Chinese Medicine from January 2017 to August 2020 were divided into control group and observation group with 25 cases in each group. Patients in the control group were given conventional comprehensive treatments such as anti-infection, improvement of organ function for 7 days. Patients in the observation group were treated with thymosin α1 on the basis of the conventional comprehensive treatments for 7 days. The T cell indicators such as the T cell subsets CD3⁺, CD8⁺, CD4⁺/CD8⁺ ratio before and after treatment in the two groups, inflammation indicators procalcitonin(PCT), C reactive protein(CRP) levels and TLR9, NF-κB protein expression in the TLR9 signaling pathway, disease severity indicators sequential organ failure assessment (SOFA) score and acute Physiology and chronic health evaluation (APACHE Ⅱ) score were observed. Results After treatment in the observation group, CD3⁺ increased, CD8⁺ decreased, and CD4⁺/CD8⁺ ratio increased. Compared with the control group, the difference was statistically significant (t=4.874, 3.864, 2.162, all P < 0.05). Compared with the control group, the inflammatory index PCT, CRP levels and the TLR9 and NF-KB protein expression levels in the observation group were significantly lower than those in the control group (t=4.833, 7.081, 5.871, 8.361, all P < 0.05). The disease severity indicators SOFA score and APACHE Ⅱ score decreased significantly. The SOFA score and APACHE Ⅱ score of the observation group decreased after treatment, and the degree of decline was significantly lower than that of the control group (t=3.672, 5.354, all P < 0.05). Conclusion Thymosin α1 can well regulate the immune function of patients with sepsis and reduce the inflammatory response of sepsis.
- Thymosin α1,
- Sepsis,
- T cell subsets,
- TLR9,
- Immune function

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References(28)

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Effect of thymosin α 1 on T lymphocytes and TLR9 signaling pathway in patients with sepsis

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