Effect of gamma globulin pulse therapy on patients with severe community-acquired pneumonia and on serum immune proteins and lymphocyte subsets

MA Xu-can; DING Ying-wei; ZHANG Bing-wen

doi:10.16766/j.cnki.issn.1674-4152.002095

Volume 19 Issue 9

Sep. 2021

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Article Navigation > Chinese Journal of General Practice > 2021 > 19(9): 1497-1499,1583

MA Xu-can, DING Ying-wei, ZHANG Bing-wen. Effect of gamma globulin pulse therapy on patients with severe community-acquired pneumonia and on serum immune proteins and lymphocyte subsets[J]. Chinese Journal of General Practice, 2021, 19(9): 1497-1499,1583. doi: 10.16766/j.cnki.issn.1674-4152.002095

Citation:

MA Xu-can, DING Ying-wei, ZHANG Bing-wen. Effect of gamma globulin pulse therapy on patients with severe community-acquired pneumonia and on serum immune proteins and lymphocyte subsets[J]. Chinese Journal of General Practice, 2021, 19(9): 1497-1499,1583. doi: 10.16766/j.cnki.issn.1674-4152.002095

Citation:

MA Xu-can, DING Ying-wei, ZHANG Bing-wen. Effect of gamma globulin pulse therapy on patients with severe community-acquired pneumonia and on serum immune proteins and lymphocyte subsets[J]. Chinese Journal of General Practice, 2021, 19(9): 1497-1499,1583. doi: 10.16766/j.cnki.issn.1674-4152.002095

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Effect of gamma globulin pulse therapy on patients with severe community-acquired pneumonia and on serum immune proteins and lymphocyte subsets

doi: 10.16766/j.cnki.issn.1674-4152.002095

Emergency Department, Jinhua Central Hospital, Jinhua, Zhejiang 321000, China

Funds:

2018ZYC-A123

Received Date: 2020-06-08
Available Online: 2022-02-15

Abstract

Abstract

Objective To explore the efficacy of gamma globulin pulse therapy in treating severe community-acquired pneumonia (SCAP), improving clinical symptoms and influencing the levels of serum immune protein and lymphocyte subsets. Methods A total of 100 patients with SCAP who were treated in Jinhua Central Hospital of Zhejiang Province from January 2017 to January 2020 were randomly divided into the observation group (50 cases) and control group (50 cases) by using the random number table. The control group was given symptomatic intervention, whilst the observation group received intravenous infusion of gamma globulin on the basis of the control group. After 7 days of treatment, the efficacy of the two groups was compared. Before and after treatment, the patients' partial pressure of oxygen (PaO₂), partial pressure of carbon dioxide (PaCO₂), percutaneous oxygen saturation (SpO₂), serum high-sensitivity C-reactive protein (hsCRP), procalcitonin (PCT) levels, and acute physiology and chronic health evaluation (APACHE Ⅱ) score were recorded. The serum immunoglobulin G/A/M (IgG/A/M), complement levels and lymphocyte subset ratio were measured. Results The total effective rate in the observation group (94.00%) was higher than that in the control group (80.00%, χ²=4.332, P=0.037). Moreover, the PaO₂ and SpO₂ of both groups after treatment were higher than those before treatment, and the values were higher in the observation group compared with the control group. The levels of PaCO₂, hsCRP, PCT and APACHE Ⅱ score were lower after treatment than before treatment, and they were lower in the observation group than in the control group (all P < 0.05). The IgG level of the observation group after treatment was higher than that before treatment, and the observation group had higher IgG level than the control group (P < 0.05). Moreover, the concentrations of CD4⁺ and CD4⁺/CD8⁺ in the observation group were higher after treatment than before treatment, and the observation group had higher concentrations than the control group. Meanwhile, the concentration of CD8⁺ was lower after treatment than before treatment, and the observation group had lower concentration than the control group (all P < 0.05). Conclusion Gamma globulin pulse therapy can improve the immune system function and lymphocyte subset ratio of patients with SCAP.
- Severe community-acquired pneumonia,
- Gamma globulin,
- Immunoglobulin,
- Lymphocyte subsets

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References

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Effect of gamma globulin pulse therapy on patients with severe community-acquired pneumonia and on serum immune proteins and lymphocyte subsets

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Effect of gamma globulin pulse therapy on patients with severe community-acquired pneumonia and on serum immune proteins and lymphocyte subsets

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