Volume 19 Issue 9
Sep.  2021
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(9): 1497-1499,1583
MA Xu-can, DING Ying-wei, ZHANG Bing-wen. Effect of gamma globulin pulse therapy on patients with severe community-acquired pneumonia and on serum immune proteins and lymphocyte subsets[J]. Chinese Journal of General Practice, 2021, 19(9): 1497-1499,1583. doi: 10.16766/j.cnki.issn.1674-4152.002095
Citation: MA Xu-can, DING Ying-wei, ZHANG Bing-wen. Effect of gamma globulin pulse therapy on patients with severe community-acquired pneumonia and on serum immune proteins and lymphocyte subsets[J]. Chinese Journal of General Practice, 2021, 19(9): 1497-1499,1583. doi: 10.16766/j.cnki.issn.1674-4152.002095
shu

Effect of gamma globulin pulse therapy on patients with severe community-acquired pneumonia and on serum immune proteins and lymphocyte subsets

doi: 10.16766/j.cnki.issn.1674-4152.002095

  • Emergency Department, Jinhua Central Hospital, Jinhua, Zhejiang 321000, China

Funds:

 2018ZYC-A123

  • Received Date: 2020-06-08
    Available Online: 2022-02-15
    Abstract
  •   Objective  To explore the efficacy of gamma globulin pulse therapy in treating severe community-acquired pneumonia (SCAP), improving clinical symptoms and influencing the levels of serum immune protein and lymphocyte subsets.   Methods  A total of 100 patients with SCAP who were treated in Jinhua Central Hospital of Zhejiang Province from January 2017 to January 2020 were randomly divided into the observation group (50 cases) and control group (50 cases) by using the random number table. The control group was given symptomatic intervention, whilst the observation group received intravenous infusion of gamma globulin on the basis of the control group. After 7 days of treatment, the efficacy of the two groups was compared. Before and after treatment, the patients' partial pressure of oxygen (PaO2), partial pressure of carbon dioxide (PaCO2), percutaneous oxygen saturation (SpO2), serum high-sensitivity C-reactive protein (hsCRP), procalcitonin (PCT) levels, and acute physiology and chronic health evaluation (APACHE Ⅱ) score were recorded. The serum immunoglobulin G/A/M (IgG/A/M), complement levels and lymphocyte subset ratio were measured.   Results  The total effective rate in the observation group (94.00%) was higher than that in the control group (80.00%, χ2=4.332, P=0.037). Moreover, the PaO2 and SpO2 of both groups after treatment were higher than those before treatment, and the values were higher in the observation group compared with the control group. The levels of PaCO2, hsCRP, PCT and APACHE Ⅱ score were lower after treatment than before treatment, and they were lower in the observation group than in the control group (all P < 0.05). The IgG level of the observation group after treatment was higher than that before treatment, and the observation group had higher IgG level than the control group (P < 0.05). Moreover, the concentrations of CD4+ and CD4+/CD8+ in the observation group were higher after treatment than before treatment, and the observation group had higher concentrations than the control group. Meanwhile, the concentration of CD8+ was lower after treatment than before treatment, and the observation group had lower concentration than the control group (all P < 0.05).   Conclusion  Gamma globulin pulse therapy can improve the immune system function and lymphocyte subset ratio of patients with SCAP.

     

    • FullText(HTML)
  • loading
    • References(19)
  • [1]
    LANKS C W, MUSANI A I, HSIA D W. Community-acquired pneumonia and hospital-acquired pneumonia[J]. Med Clin North Am, 2019, 103(3): 487-501. doi: 10.1016/j.mcna.2018.12.008
    [2]
    TORRES A, CHALMERS J D, DELA C C, et al. Challenges in severe community-acquired pneumonia: A point-of-view review[J]. Intensive Care Med, 2019, 45(2): 159-171. doi: 10.1007/s00134-019-05519-y
    [3]
    马文君, 贾换. 丙种球蛋白联合地塞米松治疗重症肺炎的效果[J]. 河南医学研究, 2020, 29(7): 1259-1260. doi: 10.3969/j.issn.1004-437X.2020.07.054
    [4]
    YANG L, WU E Y, TARRANT T K. Immune gamma globulin therapeutic indications in immune deficiency and autoimmunity[J]. Curr Allergy Asthma Rep, 2016, 16(8): 55. doi: 10.1007/s11882-016-0632-7
    [5]
    中华医学会呼吸病学分会. 中国成人社区获得性肺炎诊断和治疗指南(2016年版)[J]. 中华结核和呼吸杂志, 2016, 39(4): 253-279. doi: 10.3760/cma.j.issn.1001-0939.2016.04.005
    [6]
    RIDER A C, FRAZEE B W. Community-acquired pneumonia[J]. Emerg Med Clin North Am, 2018, 36(4): 665-683. doi: 10.1016/j.emc.2018.07.001
    [7]
    张颜苹, 霍建民, 陈晓灿. 成人社区获得性肺炎病情评估的研究进展[J]. 临床肺科杂志, 2020, 25(1): 143-146. https://www.cnki.com.cn/Article/CJFDTOTAL-LCFK202001035.htm
    [8]
    GARNACHO-MONTERO J, BARRERO-GARCIA I, GOMEZ-PRIETO M G, et al. Severe community-acquired pneumonia: Current management and future therapeutic alternatives[J]. Expert Rev Anti Infect Ther, 2018, 16(9): 667-677. doi: 10.1080/14787210.2018.1512403
    [9]
    WUNDERINK R G. Guidelines to manage community-acquired pneumonia[J]. Clin Chest Med, 2018, 39(4): 723-731. doi: 10.1016/j.ccm.2018.07.006
    [10]
    李海. 糖皮质激素对重症社区获得性肺炎合并脓毒性休克患者的治疗效果分析[J]. 河南医学研究, 2018, 27(11): 2014-2015. doi: 10.3969/j.issn.1004-437X.2018.11.048
    [11]
    李洁, 陈滔. 人血丙种球蛋白对儿童难治性肺炎支原体肺炎的作用效果[J]. 中国妇幼保健, 2020, 35(7): 1267-1269. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB202007034.htm
    [12]
    RAMUS B, BENBRAHIM O, CHERIN P. Use of intravenous and subcutaneous human immunoglobulins[J]. Soins, 2019, 64(833): 13-18. doi: 10.1016/j.soin.2019.01.016
    [13]
    褚祝飞, 魏利锋, 周超群. 丙种球蛋白对支原体肺炎合并肺不张患儿免疫功能、炎性指标的影响[J]. 现代实用医学, 2020, 32(3): 360-362. doi: 10.3969/j.issn.1671-0800.2020.03.037
    [14]
    LEONI D, RELLO J. Severe community-acquired pneumonia: Optimal management[J]. Curr Opin Infect Dis, 2017, 30(2): 240-247. doi: 10.1097/QCO.0000000000000349
    [15]
    黄宏佳, 罗海清, 郑文枝, 等. C反应蛋白在社区获得性肺炎严重程度和预后评估中的作用[J]. 实用心脑肺血管病杂志, 2018, 26(2): 99-101. https://www.cnki.com.cn/Article/CJFDTOTAL-SYXL2018S2044.htm
    [16]
    谢君杰, 易汛, 徐昉. 临床肺部感染评分和降钙素原对评估老年重症社区获得性肺炎患者病情和预后的意义[J]. 中华实验和临床感染病杂志(电子版), 2018, 12(1): 61-64. doi: 10.3877/cma.j.issn.1674-1358.2018.01.012
    [17]
    CATAUDELLA E, GIRAFFA C M, DIMARCA S, et al. Neutrophil-to-lymphocyte ratio: An emerging marker predicting prognosis in elderly adults with community-acquired pneumonia[J]. J Am Geriatr Soc, 2017, 65(8): 1796-1801. doi: 10.1111/jgs.14894
    [18]
    代岩. 丙种球蛋白对重症肺炎患者血清细胞因子及免疫功能的影响[J]. 中国临床医生杂志, 2018, 46(7): 772-774. doi: 10.3969/j.issn.2095-8552.2018.07.006
    [19]
    GUELL E, MARTIN-FERNANDEZ M, DELATORRE M C, et al. Impact of lymphocyte and neutrophil counts on mortality risk in severe community-acquired pneumonia with or without septic shock[J]. J Clin Med, 2019, 8(5): 754. doi: 10.3390/jcm8050754
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(5)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (146) PDF downloads(12) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return