Volume 19 Issue 9
Sep.  2021
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(9): 1500-1503
HUANG Yi-gui, CHEN Yu, FU Zheng-gao, ZHONG Pei-xiong, HAO Jin-xiang, XU Mei-sha, ZHOU You-ling. Risk factors of carbapenem-resistant Acinetobacter baumannii infection in a hospital[J]. Chinese Journal of General Practice, 2021, 19(9): 1500-1503. doi: 10.16766/j.cnki.issn.1674-4152.002096
Citation: HUANG Yi-gui, CHEN Yu, FU Zheng-gao, ZHONG Pei-xiong, HAO Jin-xiang, XU Mei-sha, ZHOU You-ling. Risk factors of carbapenem-resistant Acinetobacter baumannii infection in a hospital[J]. Chinese Journal of General Practice, 2021, 19(9): 1500-1503. doi: 10.16766/j.cnki.issn.1674-4152.002096
shu

Risk factors of carbapenem-resistant Acinetobacter baumannii infection in a hospital

doi: 10.16766/j.cnki.issn.1674-4152.002096

  • Department of Respiratory, the Third People's Hospital of Haikou, Haikou, Hainan 571100, China

Funds:

 17A200817

  • Received Date: 2020-12-21
    Available Online: 2022-02-15
    Abstract
  •   Objective  To explore and analyse risk factors affecting carbapenem-resistant Acinetobacter baumannii (CRAB) infection in our hospital and to provide evidence for infection prevention and control and clinical treatment.   Methods  From January 2017 to December 2019, 572 patients with Acinetobacter baumannii (AB) infection in our hospital were selected as the research objects. According to the results of drug sensitivity, they were divided into the CRAB group (387 cases) and carbapenem-sensitive Acinetobacter baumannii (CSAB) group (185 cases). The clinical data of both groups were collected. Single-factor and multivariate logistic regression were used to analyse the risk factors of CRAB infection.   Results  Amongst 572 patients with AB infection, the CRAB infection rate was 67.66% (387/572). Univariate analysis showed that history of diabetes, chronic lung disease, use of incision drainage tube, bronchoscopy, use of adrenal glucocorticoids, use of tigecycline, use of carbapenem antibiotics and use β-lactamase inhibitor antibiotics of CRAB group and CSAB group were statistically significant (all P < 0.05). Multivariate logistic regression analysis showed that diabetes history (OR=2.884, 95% CI: 1.105-7.206), use of incision drainage tube (OR=5.106, 95% CI: 1.834-14.270), bronchoscopy (OR=4.497, 95% CI: 1.704-12.365), use of tigecycline (OR=3.514, 95% CI: 1.482-8.945) and use of carbapenem antibiotics (OR=5.282, 95% CI: 2.146-15.308) were risk factors for CRAB infection (all P < 0.05).   Conclusion  Many risk factors are associated with CRAB infection. The management of patients with CRAB infection should be strengthened, and antibiotics should be used rationally to reduce the CRAB infection rate.

     

    • FullText(HTML)
  • loading
    • References(15)
  • [1]
    LIN Y T, CHENG Y H, CHUANG C, et al. Molecular and clinical characterization of multidrug-resistant and hypervirulent Klebsiella pneumoniae strains from liver abscess in Taiwan[J]. Antimicrob Agents Chemother, 2020, 64(5): e00174-20. DOI: 10.1128/AAC.00174-20.
    [2]
    LI S, DUAN X, PENG Y, et al. Molecular characteristics of carbapenem-resistant Acinetobacter spp. from clinical infection samples and fecal survey samples in Southern China[J]. BMC Infect Dis, 2019, 19(1): 900. doi: 10.1186/s12879-019-4423-3
    [3]
    DU X, XU X, YAO J, et al. Predictors of mortality in patients infected with carbapenem-resistant Acinetobacter baumannii: A systematic review and meta-analysis[J]. Am J Infect Control, 2019, 47(9): 1140-1145. doi: 10.1016/j.ajic.2019.03.003
    [4]
    BRIN A J. Epidemiology of carbapenem-resistant Gram-negative infections globally[J]. Curr Opin Infect Dis, 2019, 32(6): 609-616. doi: 10.1097/QCO.0000000000000608
    [5]
    胡付品, 郭燕, 朱德妹, 等. 2017年CHINET中国细菌耐药性监测[J]. 中国感染与化疗杂志, 2018, 18(3): 241-251. https://www.cnki.com.cn/Article/CJFDTOTAL-KGHL201803001.htm
    [6]
    朱秋丽, 卫菊, 胡丹, 等. 耐碳青霉烯类鲍曼不动杆菌下呼吸道感染的危险因素研究[J]. 中国消毒学杂志, 2019, 36(5): 359-361, 364. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXD201905013.htm
    [7]
    胡付品, 郭燕, 朱德妹, 等. 2016年中国CHINET细菌耐药性监测[J]. 中国感染与化疗杂志, 2017, 17(5): 481-491. https://www.cnki.com.cn/Article/CJFDTOTAL-KGHL201705001.htm
    [8]
    SULTAN A M, SELIEM W A. Identifying risk factors for healthcare-associated infections caused by carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit[J]. Sultan Qaboos Univ Med J, 2018, 18(1): e75-e80. doi: 10.18295/squmj.2018.18.01.012
    [9]
    杜鸣, 陈敏, 周莹, 等. 耐碳青霉烯鲍曼不动杆菌感染及预后的危险因素分析[J]. 中国医院药学杂志, 2018, 38(11): 1196-1200. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYZ201811016.htm
    [10]
    张建武, 沈平华, 郭清莲. 耐碳青霉烯类鲍曼不动杆菌的临床危险因素[J]. 武汉大学学报(医学版), 2017, 38(5): 775-779. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYK201705020.htm
    [11]
    IBRAHIM M E. Prevalence of Acinetobacter baumannii in Saudi Arabia: Risk factors, antimicrobial resistance patterns and mechanisms of carbapenem resistance[J]. Ann Clin Microbiol Antimicrob, 2019, 18(1). DOI: 10.1186/s12941-018-0301-x.
    [12]
    张欧, 林伟浩, 陈碧颜, 等. 耐碳青霉烯类鲍曼不动杆菌医院感染的危险因素研究[J]. 中国消毒学杂志, 2018, 35(5): 396-397. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGXD201805026.htm
    [13]
    李雨辰, 李颖, 谢姣, 等. 某"三甲"教学医院耐碳青霉烯类鲍曼不动杆菌感染的危险因素分析[J]. 中国药房, 2018, 29(7): 984-986. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYA201807029.htm
    [14]
    曾婷, 曾凌, 曹先伟, 等. 某三甲综合医院耐碳青霉烯类鲍曼不动杆菌感染的危险因素分析[J]. 现代预防医学, 2019, 46(7): 1334-1338. https://www.cnki.com.cn/Article/CJFDTOTAL-XDYF201907047.htm
    [15]
    许蓓妮, 陈敏珊, 伍国达, 等. 外科术后耐碳青霉烯类鲍曼不动杆菌感染的危险因素分析[J]. 新医学, 2019, 50(1): 47-50. https://www.cnki.com.cn/Article/CJFDTOTAL-XYXX201901011.htm
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(6)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (277) PDF downloads(5) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return