Volume 19 Issue 9
Sep.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(9): 1507-1509,1607
HU Zhi-min, ZHANG Yong, QIAN Chao-xia. Clinical observation of high-intensity non-invasive positive pressure ventilation in the treatment of AECOPD patients complicated with type Ⅱ respiratory failure[J]. Chinese Journal of General Practice, 2021, 19(9): 1507-1509,1607. doi: 10.16766/j.cnki.issn.1674-4152.002098
Citation: HU Zhi-min, ZHANG Yong, QIAN Chao-xia. Clinical observation of high-intensity non-invasive positive pressure ventilation in the treatment of AECOPD patients complicated with type Ⅱ respiratory failure[J]. Chinese Journal of General Practice, 2021, 19(9): 1507-1509,1607. doi: 10.16766/j.cnki.issn.1674-4152.002098
shu

Clinical observation of high-intensity non-invasive positive pressure ventilation in the treatment of AECOPD patients complicated with type Ⅱ respiratory failure

doi: 10.16766/j.cnki.issn.1674-4152.002098
  • 1.

    Department of Respiratory and Critical Care Medicine, Bengbu Third People's Hospital Affiliated to Bengbu Medical College, Bengbu, Anhui 233000, China

Funds:

 1804h08020287

  • Received Date: 2020-12-25
    Available Online: 2022-02-15
    Abstract
  •   Objective  To investigate the effect of high-intensity and conventional pressure non-invasive positive pressure ventilation in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with type Ⅱ respiratory failure.   Methods  A total of 72 patients with AECOPD and type Ⅱ respiratory failure in the Respiratory Department of Bengbu Third Hospital from October 2018 to January 2020 were included. They were divided into the high-intensity group (36 cases) and conventional pressure group (36 cases) by simple random method. The inspiratory pressure was set to (24.7±1.8) cm H2O and (16.1±1.2) cm H2O, respectively. The pH, PaCO2, PaO2 between the two groups and within 2, 6, 24, 48, 72 h after treatment, adverse effects of non-invasive ventilation, tracheal intubation rate and fatality rate, hospitalisation days, re-admission rate 28 days after discharge and 6-minute walking distance were compared.   Results  The differences in pH, PaO2 and PaCO2 between both groups before treatment were not statistically significant (all P>0.05). The differences in pH and adverse reactions after treatment were not statistically significant (all P>0.05). The differences in PaO2 and PaCO2 were statistically significant (all P>0.05). The tracheal intubation rate was 8.33% (3/36) and 13.89% (5/36). The fatality rate was 2.78% (1/36) and 8.33% (3/36); the difference were not statistically significant (all P>0.05). The number of hospitalisation days were (10.0±1.7) and (13.2±1.9) days. The difference was statistically significant (P < 0.05). No significant difference was observed in the readmission rate and 6-min walking distance of patients 28 days after discharge (both P>0.05).   Conclusion  The application of high-intensity non-invasive positive pressure ventilation can improve PaO2 and PaCO2 in patients with AECOPD combined with type Ⅱ respiratory failure more quickly, without a significant increase in adverse reactions. Moreover and shorten the hospital stay.

     

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