Circulatory system manifestations of antiphospholipid antibody syndrome

ZHANG Jin; LI Cheng; HAN Xiao-rong; CHEN Zhong-bo; WANG Ying-hui; WANG Hong; WANG Yong-gang

doi:10.16766/j.cnki.issn.1674-4152.002111

Volume 19 Issue 9

Sep. 2021

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Article Navigation > Chinese Journal of General Practice > 2021 > 19(9): 1557-1561

ZHANG Jin, LI Cheng, HAN Xiao-rong, CHEN Zhong-bo, WANG Ying-hui, WANG Hong, WANG Yong-gang. Circulatory system manifestations of antiphospholipid antibody syndrome[J]. Chinese Journal of General Practice, 2021, 19(9): 1557-1561. doi: 10.16766/j.cnki.issn.1674-4152.002111

Citation:

ZHANG Jin, LI Cheng, HAN Xiao-rong, CHEN Zhong-bo, WANG Ying-hui, WANG Hong, WANG Yong-gang. Circulatory system manifestations of antiphospholipid antibody syndrome[J]. Chinese Journal of General Practice, 2021, 19(9): 1557-1561. doi: 10.16766/j.cnki.issn.1674-4152.002111

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Circulatory system manifestations of antiphospholipid antibody syndrome

doi: 10.16766/j.cnki.issn.1674-4152.002111

Department of Cardiology, the First Hospital of Jilin University, Changchun, Jilin 130000, China

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20190701066GH

JJKH20201046KJ

Received Date: 2020-07-10
Available Online: 2022-02-15

Abstract

Abstract

Antiphospholipid syndrome is an autoimmune disease characterized by persistent positive antiphospholipid antibodies in the blood and associated with the risk of thrombosis, miscarriage and other disorders. The current diagnosis of antiphospholipid syndrome is based on meeting at least one of the clinical manifestations in the latest Sapporo Classification Criteria and at least one clinical laboratory standard. At present, antiphospholipid syndrome is more and more considered as a multi-organ and multi-system disease, and its clinical manifestation spectrum is gradually expanding, which can involve different organ systems. The circulatory system is one of the main target organ systems involved in antiphospholipid syndrome. The pathogenesis of antiphospholipid syndrome is mainly manifested in two aspects, namely, autoimmunity and thrombosis. The common clinical manifestations of circulatory involvement include thrombosis, valvular heart disease, ischemic cardiomyopathy, atherosclerosis, pulmonary hypertension and ventricular dysfunction. Non-invasive imaging techniques such as vascular ultrasound, echocardiography, computed tomography, magnetic resonance imaging and nuclear medical examination are the preferred methods used for investigating the circulatory system manifestations associated with antiphospholipid syndrome. Invasive heart tests, such as coronary arteriography, increase the risk of clots and are not recommended as routine tests. Anticoagulation is the basis of treatment of patients with antiphospholipid syndrome. The anticoagulation regimen should be selected on the basis of risk stratification of patients with antiphospholipid syndrome. The feasibility of percutaneous coronary intervention and surgical intervention is still controversial in patients with antiphospholipid syndrome. This review describes the possible circulatory manifestations, pathogenesis, imaging examination and treatment strategies of patients with antiphospholipid syndrome.
- Antiphospholipid syndrome,
- Antiphospholipid antibodies,
- Valvular heart disease,
- Ischemic heart disease,
- Atherosclerosis,
- Pulmonary hypertension

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References

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Circulatory system manifestations of antiphospholipid antibody syndrome

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