Volume 19 Issue 9
Sep.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(9): 1562-1564
ZHANG Xiao-hua, QIAN Feng, ZHAI Ying, SUN Ying, ZHOU Jie, ZHOU Shu-ping, LIU Shu-rong. Clinical study of Jiedu Tongmai Granule for the treatment of lower extremity arteriosclerosis obliterans[J]. Chinese Journal of General Practice, 2021, 19(9): 1562-1564. doi: 10.16766/j.cnki.issn.1674-4152.002112
Citation: ZHANG Xiao-hua, QIAN Feng, ZHAI Ying, SUN Ying, ZHOU Jie, ZHOU Shu-ping, LIU Shu-rong. Clinical study of Jiedu Tongmai Granule for the treatment of lower extremity arteriosclerosis obliterans[J]. Chinese Journal of General Practice, 2021, 19(9): 1562-1564. doi: 10.16766/j.cnki.issn.1674-4152.002112
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Clinical study of Jiedu Tongmai Granule for the treatment of lower extremity arteriosclerosis obliterans

doi: 10.16766/j.cnki.issn.1674-4152.002112

  • Department of Cardiology, the First Clinical Hospital, Jilin Academy of Traditional Chinese Medicine, Changchun, Jilin 130021, China

Funds:

 2018184

  • Received Date: 2020-02-03
    Available Online: 2022-02-15
    Abstract
  •   Objective  To evaluate the clinical efficacy of Jiedu Tongmai Granule for the treatment of lower extremity arteriosclerosis obliterans (ASO) and provide clinical case data for the development of hospital preparations.  Methods  Seventy-two patients with ASO were randomly divided into a treatment group and a control group, with 36 cases in each group. The treatment group was administered with Western medicine and additionally received Jiedu Tongmai Granules (1 bag, 10 g) twice a day for 4 weeks. Before and after the treatment, ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV) and TCM syndrome scores were observed and the clinical efficacy was evaluated.  Results  With regard to the curative effects of TCM syndrome, the total effective rate was 83.3% in the treatment group and 58.3% in the control group. Results of rank sum test showed that the treatment group was superior to the control group, and the difference was statistically different (P < 0.05). After the treatment, ABI in both groupswassignificantly improved (P < 0.05). After the treatment, baPWV decreased with varying degrees in both groups, and the difference was statistically significant (all P < 0.05). After the treatment, the difference between the two groups on the right side was statistically significant (P < 0.05). The clinical efficacy of Jiedu Tongmai Granule for the treatment of ASO was better in the treatment group than that in the control group. However, the difference between the two groups on the left side was not statistically significant (P>0.05).  Conclusion  For patients with ASO, the addition of Jiedu Tongmai Granule to the standardised treatment using Western medicines can alleviate the clinical symptoms, increase ABI index and decrease baPWV level, thereby reducing the clinical symptoms, improving the clinical signs, and enhancing the quality of life of patients. This study provides guidance for further research on and wide clinical applications of Jiedu Tongmai Granule.

     

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