Volume 19 Issue 9
Sep.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(9): 1593-1596
JIN Jing, ZHOU Yi-nong, JIANG Ming, ZHENG Jie, ZHAN Lin-sen. Effects of goal-directed colloid infusion on short-term recovery and immune function during colorectal cancer resection[J]. Chinese Journal of General Practice, 2021, 19(9): 1593-1596. doi: 10.16766/j.cnki.issn.1674-4152.002119
Citation: JIN Jing, ZHOU Yi-nong, JIANG Ming, ZHENG Jie, ZHAN Lin-sen. Effects of goal-directed colloid infusion on short-term recovery and immune function during colorectal cancer resection[J]. Chinese Journal of General Practice, 2021, 19(9): 1593-1596. doi: 10.16766/j.cnki.issn.1674-4152.002119
shu

Effects of goal-directed colloid infusion on short-term recovery and immune function during colorectal cancer resection

doi: 10.16766/j.cnki.issn.1674-4152.002119
  • 1.

    Department of General Surgery, Zhejiang Quzhou City People's Hospital, Quzhou, Zhejiang 324000, China

Funds:

 2019RC306

  • Received Date: 2020-11-11
    Available Online: 2022-02-15
    Abstract
  •   Objective  To analyse the clinical value of goal-directed infusion of colloidal fluid in promoting short-term recovery and improving immune function in patients undergoing colorectal cancer resection.  Methods  The clinical data of 164 colorectal cancer resection patients who underwent colorectal cancer resection in our hospital from January 2019 to August 2020 were retrospectively analysed. According to whether colloidal fluid was injected after intraoperative general anaesthesia induction, the observation group (86 cases) received colloidal fluid peripherally, whilst the control group (78 cases) received crystal fluid peripherally. The perioperative information, central venous oxygen saturation (ScvO2), lactate (Lac) and blood glucose (Glu) concentrations at different time points, the occurrence of surgical complications, and the level of humoral immunity in both groups were compared.  Results  No statistically significant differences were observed in both groups in terms of operation time, intraoperative blood loss, fluid replacement and urine volume (all P>0.05). The first exhaust time, defecation time, half flow diet time and hospital stay in the observation group were shorter than those in the control group (all P < 0.05). At the end of surgery, the concentrations of ScvO2, Lac and Glu in both groups were not statistically significant (all P>0.05). The incidence of nausea and vomiting in the observation group was 8.14%, which was lower than that in the control group (20.51%), and the difference was statistically significant (P < 0.05). Postoperative humoral immune indexes in both groups were lower than those before surgery. Three days after surgery, the serum IgG and C4 levels in the observation group were higher than those in the control group, and the difference was statistically significant (P < 0.05).  Conclusion  Goal-directed infusion of colloidal fluid can shorten the length of hospital stay, reduce nausea and vomiting and protect the immune function of patients after colorectal cancer resection, which deserves further research and application.

     

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