Volume 19 Issue 10
Oct.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(10): 1693-1696
QIN Wei, HUANG Xiao-hong, HUANG Hui-lian. Expression and clinical significance of HIF-1α, VEGF and AMH in patients with polycystic ovary syndrome[J]. Chinese Journal of General Practice, 2021, 19(10): 1693-1696. doi: 10.16766/j.cnki.issn.1674-4152.002144
Citation: QIN Wei, HUANG Xiao-hong, HUANG Hui-lian. Expression and clinical significance of HIF-1α, VEGF and AMH in patients with polycystic ovary syndrome[J]. Chinese Journal of General Practice, 2021, 19(10): 1693-1696. doi: 10.16766/j.cnki.issn.1674-4152.002144
shu

Expression and clinical significance of HIF-1α, VEGF and AMH in patients with polycystic ovary syndrome

doi: 10.16766/j.cnki.issn.1674-4152.002144
  • 1.

    Department of Obstetrics and Gynecology, Huzhou Central Hospital, Huzhou Normal College Affiliated Central Hospital, Huzhou, Zhejiang 313003, China

Funds:

 2019ZH043

  • Received Date: 2021-02-18
    Available Online: 2022-02-15
    Abstract
  •   Objective   To study the expression of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and anti-Mullerian hormone (AMH) in polycystic ovary syndrome (PCOS) and to explore their clinical significance.   Methods   A total of 130 cases of PCOS patients in our hospital from June 2018 to June 2020 were selected as the observation group, and 100 healthy women were recruited as the control group. The levels of follicle stimulating hormone (FSH), luteinising hormone (LH), prolactin (PRL), testosterone (T), progesterone (P) and estradiol (E2) were measured by immunochemiluminescence. The serum HIF-1α, VEGF and AMH levels were detected by enzyme-linked immunosorbent assay. The correlation between HIF-1α, VEGF and AMH and the predictive value of PCOS clinical significance were analysed.   Results   The levels of FSH [(5.81±0.92) mU/mL], LH [(10.54±0.72) mU/mL], PRL [(398.55±80.47) ng/mL], T [(7.76±2.27) nmol/L], P [(5.29±0.92) nmol/L] and E2 [(118.63±42.78) pmol/L] in the observation group were significantly higher than those in the control group (t=3.179, 12.150, 4.284, 11.223, 43.724 and 3.955, all P < 0.05). The levels of HIF-1α [(163.12±25.17) pg/L], VEGF [(257.03±30.45) pg/L] and AMH [(7.29±1.02) pg/L] in the observation group were significantly higher than those in the control group (t=42.592, 31.612 and 47.194, all P < 0.05). HIF-1α was positively correlated with VEGF and AMH levels (r=0.811, 0.848 and 0.762, all P < 0.05). The areas under the curve of serum HIF-1α, VEGF and AMH were 0.764, 0.731 and 0.742, and 95% confidence intervals were 0.681-0.852, 0.634-0.819 and 0.649-0.827, respectively.   Conclusion   The levels of HIF-1α, VEGF and AMH in patients with PCOS are significantly increased, which have high predictive value for PCOS and can be used as clinical diagnostic indicators.

     

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