Volume 19 Issue 10
Oct.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(10): 1717-1720, 1783
TAO Tao, HE Ling-ling, ZHANG Ye-min. Association of related markers in blood routine examination with diagnosis and severity of acute cerebral infarction[J]. Chinese Journal of General Practice, 2021, 19(10): 1717-1720, 1783. doi: 10.16766/j.cnki.issn.1674-4152.002150
Citation: TAO Tao, HE Ling-ling, ZHANG Ye-min. Association of related markers in blood routine examination with diagnosis and severity of acute cerebral infarction[J]. Chinese Journal of General Practice, 2021, 19(10): 1717-1720, 1783. doi: 10.16766/j.cnki.issn.1674-4152.002150
shu

Association of related markers in blood routine examination with diagnosis and severity of acute cerebral infarction

doi: 10.16766/j.cnki.issn.1674-4152.002150
  • 1.

    Department of Clinical Laboratory of Chaohu Hospital Affiliated to Anhui Medical University, Hefei, Anhui 238000, China

Funds:

 81671316

 2020xjk214

  • Received Date: 2021-04-16
    Available Online: 2022-02-15
    Abstract
  •   Objective  To investigate the relationship between diagnosis and severity of acute cerebral infarction (ACI) and neutrophil/lymphocyte ratio (NLR) and mean platelet volume/lymphocyte ratio (MPVLR).  Methods  From October August 2018 to June 2020, 125 ACI patients from Chaohu Hospital Affiliated to Anhui Medical University who were admitted within 24 h after onset were enrolled. They were divided into the mild ACI group (NIHSS < 5 points, n=70) and moderate and severe ACI group (NIHSS ≥ 5 points, n=55) according to the National Institutes of Health Stroke Scale (NIHSS) score. Another 75 healthy volunteers examined in our physical examination centre were selected as the control group. The values of NLR and MPVLR in predicting ACI were determined by constructing receiver operating characteristic curves. Pearson correlation analysis was used to evaluate the correlation between NE, NLR, MPVLR, PNR, and LYM and NIHSS score. The independent risk factors of ACI severity were analysed by multivariate logistic regression analysis.  Results  Serum MPV, NLR and MPVLR levels in the ACI group were significantly higher, whilst the levels of LYM and PNR were significantly lower than those of the control group (P < 0.05). The levels of NLR and MPVLR in the moderate and severe ACI group were significantly higher, whilst the levels of PNR and LYM were obviously lower than those in the mild ACI group (P < 0.05). The areas under the curve of NLR and MPVLR to predict ACI were 0.739 (0.672-0.806) and 0.704 (0.632-0.776), respectively. The NE, NLR and MPVLR levels in ACI were positively correlated with the NIHSS score (r=0.475, 0.582, 0.220, P < 0.05). The PNR and LYM levels were negatively correlated with the NIHSS score (r=-0.359, -0.223, P < 0.05). NLR was an independent risk factor for the severity of ACI (P < 0.05).  Conclusion  NLR and MPVLR have certain clinical significance for ACI diagnosis and evaluating the severity of ACI. NLR may be an independent risk factor for the severity of ACI. Monitoring these two indicators has a certain guiding value for the early evaluation and treatment of ACI.

     

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