Volume 19 Issue 11
Nov.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(11): 1843-1845,1915
QI Ruo-bing, YANG Yong-xiu, JIANG Hui-quan, YIN Xiao-wen, CHEN Bin-hua, FEI Jian-hui, LEI Lan-ying, ZHANG Xue-ping. Efficacy analysis of donepezil and memogen combined with risperidone in the treatment of mental behavioural symptoms of Alzheimer's disease[J]. Chinese Journal of General Practice, 2021, 19(11): 1843-1845,1915. doi: 10.16766/j.cnki.issn.1674-4152.002181
Citation: QI Ruo-bing, YANG Yong-xiu, JIANG Hui-quan, YIN Xiao-wen, CHEN Bin-hua, FEI Jian-hui, LEI Lan-ying, ZHANG Xue-ping. Efficacy analysis of donepezil and memogen combined with risperidone in the treatment of mental behavioural symptoms of Alzheimer's disease[J]. Chinese Journal of General Practice, 2021, 19(11): 1843-1845,1915. doi: 10.16766/j.cnki.issn.1674-4152.002181
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Efficacy analysis of donepezil and memogen combined with risperidone in the treatment of mental behavioural symptoms of Alzheimer's disease

doi: 10.16766/j.cnki.issn.1674-4152.002181

  • Department of Gerontology, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang 310013, China

Funds:

 2018KY610

  • Received Date: 2020-12-11
    Abstract
  •   Objective  To analyse the efficacy and safety of donepezil and memantine combined with risperidone in the treatment of behavioural and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease (AD).  Methods  A total of 150 patients with AD and BPSD who were admitted to Hangzhou Seventh People's Hospital from January 2017 to June 2019 were randomly divided into risperidone group (group A), risperidone+donepezil group (group B) and risperidone+donepezil+memogen group (group C) through a random number method, with 50 patients in each group. Before treatment, the positive and negative syndrome scale (PANSS), MOCA scale, blood sugar, triglyceride and cholesterol were recorded. Twelve weeks after treatment, the PANSS, MOCA scale, treatment emergent symptom scale (TESS), blood sugar, triglyceride, cholesterol test of the three groups were compared, with special attention to PANSS, MOCA scale, blood glucose, blood lipids and adverse reactions.  Results  After treatment, the MOCA and PANSS scores of group C patients were significantly improved compared with those of the other two groups. MOCA score of group A [(14.86±3.78) points], group B [(16.94±3.57) points] and group C [(19.10±3.73) points], the difference was statistically significant (F=9.858, P < 0.05). PANSS scores were (110.52±11.55) points in group A, (99.96±8.47) points in group B and (86.14±5.48) points in group C, and the difference was statistically significant (F=94.100, P < 0.05). The incidence of adverse reactions was lower in group C than that in the other two groups, and the results were statistically significant. After treatment, the improvement of blood glucose, blood lipid, TESS and risperidone dosage in group C was more obvious than that in groups A and B.  Conclusion  Risperidone+donepezil group and risperidone+donepezil+memantine groups have better cognitive function improvement after treatment of BPSD, less side effects, reduced dose of risperidone drug treatment and improved quality of life.

     

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