Volume 19 Issue 11
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(11): 1884-1887
YAN Meng-jie, GU Mao-hong, XU You-di. Study on the correlations between heat shock protein 70 and severe preeclampsia[J]. Chinese Journal of General Practice, 2021, 19(11): 1884-1887. doi: 10.16766/j.cnki.issn.1674-4152.002192
Citation: YAN Meng-jie, GU Mao-hong, XU You-di. Study on the correlations between heat shock protein 70 and severe preeclampsia[J]. Chinese Journal of General Practice, 2021, 19(11): 1884-1887. doi: 10.16766/j.cnki.issn.1674-4152.002192
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Study on the correlations between heat shock protein 70 and severe preeclampsia

doi: 10.16766/j.cnki.issn.1674-4152.002192

  • Department of Obstetrics, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, China

Funds:

 F-201661

  • Received Date: 2020-08-03
    Available Online: 2022-02-15
    Abstract
  •   Objective  To observe and compare the clinical characteristics of early-onset and late-onset severe preeclampsia (EOSP and LOSP), and to explore the correlation between heat shock protein 70 (HSP70) and severe preeclampsia.  Methods  The clinical characteristics of 84 EOSP cases and 252 LOSP cases in Nanjing First Hospital from July 2013 to March 2020 were retrospectively analyzed. Enzyme-linked immunosorbent assay was used to detect the serum HSP70 levels of EOSP group, LOSP group and 448 normal full-term pregnancy group. The differences in the results amongst the three groups were compared.  Results  There were statistical differences in ages, pre-pregnant BMI, onset gestational weeks, delivery gestational weeks, days of expectation treatment, blood pressure (systolic and diastolic blood pressure), 24 h urinary protein quantity (24h-Upr), creatinine (Cre), blood urea nitrogen (BUN), alanine transaminase (ALT), aspartate aminotransferase (AST), and platelet count (PLT) between the EOSP and LOSP groups (all P < 0.05). The values of HSP70 in the EOSP group [(101.81±6.44) ng/mL] was significantly higher than that in the LOSP group [(86.51±10.70) ng/mL, P < 0.05], while the HSP70 levels in the control group [(51.33±15.48) ng/mL] was significantly higher than LOSP group (P < 0.01).  Conclusion  HSP70 levels in the severe preeclampsia group is significantly higher than that in the normal pregnancy, and it is higher in the EOSP group than that in the LOSP group, indicating that Hsp70 in serum may be related to the pathogenesis of severe preeclampsia.

     

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