Volume 19 Issue 11
Nov.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(11): 1908-1911
LI Ao-hang, TIAN Yuan-yuan, GAO Yan, ZHANG Jin-fang. Application value of H-FABP, RDW and NT-proBNP levels in the diagnosis of acute non ST segment elevation myocardial infarction[J]. Chinese Journal of General Practice, 2021, 19(11): 1908-1911. doi: 10.16766/j.cnki.issn.1674-4152.002198
Citation: LI Ao-hang, TIAN Yuan-yuan, GAO Yan, ZHANG Jin-fang. Application value of H-FABP, RDW and NT-proBNP levels in the diagnosis of acute non ST segment elevation myocardial infarction[J]. Chinese Journal of General Practice, 2021, 19(11): 1908-1911. doi: 10.16766/j.cnki.issn.1674-4152.002198
shu

Application value of H-FABP, RDW and NT-proBNP levels in the diagnosis of acute non ST segment elevation myocardial infarction

doi: 10.16766/j.cnki.issn.1674-4152.002198

  • Clinical Laboratory Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Funds:

 81802064

  • Received Date: 2021-01-22
    Available Online: 2022-02-15
    Abstract
  •   Objective  To investigate the application value of heart-type fatty acid binding protein (H-FABP), red blood cell volume distribution width (RDW) and terminal pro brain natriuretic peptide (NT-proBNP) levels in the diagnosis of acute non ST segment elevation myocardial infarction (NSTEMI) and to provide a reference for the clinical diagnosis of NSTEMI.  Methods  Forty-five patients with acute NSTEMI who were admitted to our hospital from January 2019 to January 2020 were designated as the NSTEMI group, and they were divided into mild, moderate and severe groups according to Gensini score. Forty-five patients with noncardiogenic chest pain and angina pectoris in the same period were designated as non-NSTEMI group. Forty-five healthy people were designated as the control group. The levels of H-FABP, RDW and NT proBNP in each group were compared to analyse the diagnostic value of those in the NSTEMI group.  Results  The levels of H-FABP, RDW and NT-proBNP in the NSTEMI group were higher than those in the non-NSTEMI and control groups, and the levels of H-FABP, RDW and NT-proBNP in the non-NSTEMI group were apparently higher than those in the control group (all P < 0.05). The levels of H-FABP, RDW and NT-proBNP in the severe NSTEMI group were apparently higher than those in the mild and moderate groups, and the levels of H-FABP, RDW and NT-proBNP in the moderate NSTEMI group were apparently higher than those in the mild group (all P < 0.05). The levels of H-FABP, RDW and NT-proBNP in NSTEMI patients were positively correlated with Gensini score (all P < 0.05). The AUC values of PH-FABP, RDW and NT-proBNP alone and in the combined diagnosis of NSTEMI were 0.813, 0.758, 0.866 and 0.887, respectively.  Conclusion  Serum ph-FABP, RDW and NT-probNP participate in the occurrence and development of acute NSTEMI, the level of which increased gradually with the aggravation of the illness of patients with acute NSTEMI. The combined detection of ph-FABP, RDW and NT-probNP have a higher diagnostic value for NSTEMI.

     

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