Volume 19 Issue 12
Dec.  2021
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(12): 2028-2030
HUANG Min, LI Dong-dong, LIU Chuan-miao. Analysis of clinical short-term prognostic factors in patients with hepatitis B-related acute-on-chronic liver failure[J]. Chinese Journal of General Practice, 2021, 19(12): 2028-2030. doi: 10.16766/j.cnki.issn.1674-4152.002227
Citation: HUANG Min, LI Dong-dong, LIU Chuan-miao. Analysis of clinical short-term prognostic factors in patients with hepatitis B-related acute-on-chronic liver failure[J]. Chinese Journal of General Practice, 2021, 19(12): 2028-2030. doi: 10.16766/j.cnki.issn.1674-4152.002227
shu

Analysis of clinical short-term prognostic factors in patients with hepatitis B-related acute-on-chronic liver failure

doi: 10.16766/j.cnki.issn.1674-4152.002227

  • Department of Infection, the First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, China

Funds:

 KJ2017A247

  • Received Date: 2021-07-28
    Available Online: 2022-03-02
    Abstract
  •   Objective  To explore the relationship between the model for end-stage liver disease (MELD) score, total bilirubin, albumin, international normalized ratio and prothrombin activity and the prognosis in patients with hepatitis B-related acute-on-chronic liver failure (ACLF).  Methods  A total of 124 patients with hepatitis B-related ACLF who were admitted from January 2018 to December 2020 were collected from the Department of Infection, the First Affiliated Hospital of Bengbu Medical University. The relevant indexes of liver function and coagulation function were collected, and whether the patients were treated with artificial liver or not, and the MELD score was also evaluated. On the basis of the clinical outcome after 90-day admission, the patients were divided into the survival group and death group. Data of MELD score, total bilirubin, albumin, international normalized ratio and prothrombin activity were compared between the two groups. Logistic regression analysis was used to study the relationship between various indexes and the prognosis of HBV-ACLF patients.  Results  The MELD score, the international normalized ratio and the total and the ages bilirubin in the survival group were (22.66±4.69) scores, 1.72±0.42 and (281.09±94.21) μmol/L and (40.54±7.39) ages, respectively, which were significantly lower than those in the death group [(31.38±5.39) scores, 2.64±0.61 and (360.54±130.97) μmol/L and (45.73±12.72) ages], all of the differences were statistically significant (all P < 0.05). The albumin and prothrombin activity in the survival group were (31.21±3.83) g/L and (35.95±11.82)%, respectively, which were significantly higher than those in the death group [(28.43±4.46) g/L and (29.54±12.10)%)], all of the differences were statistically significant (all P < 0.05). Logistic regression analysis showed that the higher MELD score, the higher level of TBIL, the higher level of INR and the elder age were considered as independent risk factors of ACLF patients, and albumin and prothrombin activity were considered as protective factors of ACLF patients.  Conclusion  The MELD score, total bilirubin, albumin, international normalized ratio and prothrombin activity can be used as prognostic predictors in sepsis patients.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组. 肝衰竭诊治指南(2018年版)[J]. 中华肝脏病杂志, 2019, 27(1): 18-26. doi: 10.3760/cma.j.issn.1007-3418.2019.01.006
    [2]
    LAI J, LIU Y, PAN C, et al. Interleukin-1 receptor antagonist expression is inversely associated with outcomes of hepatitis B related acute-on-chronic liver failure[J]. Exp Ther Med, 2017, 13(6): 2867-2875. doi: 10.3892/etm.2017.4361
    [3]
    LEÃO G S, LUNARDI F L, PICON R V. Acute-on-chronic liver failure: A comparison of three different diagnostic criteria[J]. Ann Hepatol, 2019, 18(2): 373-378. doi: 10.1016/j.aohep.2019.01.001
    [4]
    中华医学会感染病学分会, 中华医学会肝病分会. 慢性乙型肝炎防治指南(2019年版)[J]. 中华传染病杂志, 2019, 37(12): 711-736. doi: 10.3760/cma.j.issn.1000-6680.2019.12.003
    [5]
    黎李萍, 伍民生, 唐艳芳, 等. 重症病毒性肝炎患者医院感染病原菌特征及其与预后的关系[J]. 肝脏, 2019, 24(8): 923-924. doi: 10.3969/j.issn.1008-1704.2019.08.026
    [6]
    秦娇, 强丽, 陈文, 等. 红细胞分布宽度可作为乙型肝炎相关慢加急性肝衰竭患者短期死亡的独立预测因子[J]. 南方医科大学学报, 2018, 38(11): 1354-1359. https://www.cnki.com.cn/Article/CJFDTOTAL-DYJD201811014.htm
    [7]
    曾艳丽, 魏君锋, 丁岗强, 等. HBcAb水平预测HBeAg阳性慢性乙肝初治患者肝纤维化程度的研究[J]. 中华全科医学, 2019, 17(3): 351-354, 378. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201903004.htm
    [8]
    田小利, 彭颖, 吴松林, 等. 肝衰竭分期联合MELD评分对肝衰竭短期预后判断的研究[J]. 重庆医学, 2017, 46(8): 1079-1081. doi: 10.3969/j.issn.1671-8348.2017.08.023
    [9]
    姚运海, 甘建和, 赵卫峰. 4种评分系统对肝硬化合并感染患者预后的评估价值[J]. 临床肝胆病杂志, 2019, 35(1): 87-91. doi: 10.3969/j.issn.1001-5256.2019.01.016
    [10]
    郑三菊, 王蕾, 占国清. 低钠血症与失代偿期肝硬化患者肝脏损害程度及预后的关系[J]. 临床消化病杂志, 2017, 29(5): 271-274. doi: 10.3870/lcxh.j.issn.1005-541X.2017.05.02
    [11]
    占国清, 谭华炳, 李儒贵, 等. 肝衰竭分期、MELD评分和血清降钙素原评估乙型肝炎相关慢加急性肝衰竭患者短期预后的价值[J]. 湖北医药学院学报, 2018, 37(6): 556-559. https://www.cnki.com.cn/Article/CJFDTOTAL-YYYX201806014.htm
    [12]
    王嘉鑫, 程娜, 向天新, 等. HBV相关慢加急性肝衰竭短期预后模型的建立及评价[J]. 临床肝胆病杂志, 2019, 35(6): 1299-1303. doi: 10.3969/j.issn.1001-5256.2019.06.023
    [13]
    吴家箴, 杨兴祥, 江南. 乙肝慢加急性肝衰竭患者血清白蛋白水平和MELD评分关系分析[J]. 航空航天医学杂志, 2017, 28(7): 811-812. doi: 10.3969/j.issn.2095-1434.2017.07.017
    [14]
    李艳艳, 欧阳兵, 徐龙. 血清前白蛋白、INR及MELD评分与肝衰竭患者预后的关系[J]. 江西医药, 2019, 54(3): 228-230. https://www.cnki.com.cn/Article/CJFDTOTAL-JXYY201903015.htm
    [15]
    宁更献, 李力, 侯军良, 等. 慢加急性肝衰竭病因、临床特点与预后关系分析[J]. 河北医药, 2017, 39(2): 214-216. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYZ201702014.htm
    [16]
    王媛慧, 刘源, 岳明, 等. 应用乳酸脱氢酶建立预测模型评估慢加急性肝衰竭预后[J]. 南京医科大学学报(自然科学版), 2020, 40(7): 996-1001. https://www.cnki.com.cn/Article/CJFDTOTAL-NJYK202007012.htm
    [17]
    WU D, SUN Z, LIU X, et al. Hint: A novel prognostic model for patients with hepatitis B virus-related acute-on-chronic liver failure[J]. Aliment Pharmacol Ther, 2018, 48(7): 750-760. doi: 10.1111/apt.14927
    [18]
    DURAND F, FRANCOZ C, ASRANI S K, et al. Acute kidney injury after liver transplantation[J]. Transplantation, 2018, 102(10): 1636-1649. doi: 10.1097/TP.0000000000002305
    [19]
    胡辉, 黄贝贝, 宁玲, 等. HBV相关慢加急性肝衰竭患者短期预后预测模型的建立与评价[J]. 临床肝胆病杂志, 2020, 36(1): 123-127. doi: 10.3969/j.issn.1001-5256.2020.01.027
    [20]
    BLASI A, CALVO A, PRADO V, et al. Coagulation failure in patients with acute -on -chronic liver failure and decompensated cirrhosis: Beyond the international normalized ratio[J]. Hepatology, 2018, 68(6): 2325-2337. doi: 10.1002/hep.30103
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (145) PDF downloads(6) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return