Volume 19 Issue 12
Dec.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(12): 2065-2067, 2076
FU Xu-ming, HUANG Lie-ping, HAN Yi-yao, WANG Ji, XU Qiao, BAI Min. Comparative observation of two different doses of caffeine citrate in apnea of preterm infants[J]. Chinese Journal of General Practice, 2021, 19(12): 2065-2067, 2076. doi: 10.16766/j.cnki.issn.1674-4152.002238
Citation: FU Xu-ming, HUANG Lie-ping, HAN Yi-yao, WANG Ji, XU Qiao, BAI Min. Comparative observation of two different doses of caffeine citrate in apnea of preterm infants[J]. Chinese Journal of General Practice, 2021, 19(12): 2065-2067, 2076. doi: 10.16766/j.cnki.issn.1674-4152.002238
shu

Comparative observation of two different doses of caffeine citrate in apnea of preterm infants

doi: 10.16766/j.cnki.issn.1674-4152.002238

  • Department of Pediatrics, Zhoushan Women and Children Hospital, Zhoushan, Zhejiang 316000, China

Funds:

 2016KYB317

  • Received Date: 2020-06-12
    Available Online: 2022-03-02
    Abstract
  •   Objective  To study the effects of different doses of caffeine citrate on apnea in preterm infants.  Methods  A total of 82 cases of apnea of prematurity (AOP) preterm infants were divided into high-dose groups (41 cases) and low-dose group (41 cases) according to random number table. All children were appropriately treated with anti-infection, respiratory support and other measures. Both groups were given caffeine citrate load of 20 mg/(kg·d) 24 hours before extubation, maintenance dose of 10 mg/(kg·d) in high-dose group and 5 mg/(kg·d) in low-dose group. The efficacy, adverse reaction rate, and complication rate of the two groups of children were compared.  Results  Compared to the low-dose group, the high-dose group's effective rate was higher (46.34% vs. 68.29%), and the failure rate (31.71% vs. 12.20%), apnea time [(5.02±1.44) d vs. (2.86±1.03) d], and length of hospital stay [(23.56±6.35) d vs. (20.75±5.97) d] were lower, which differences were statistically significant (all P < 0.05). There was no significant difference in hospital stay time, oxygen treatment time, and in-hospital mortality between the two groups (all P>0.05). There was no significant difference in the incidence of tachycardia, feeding intolerance, hyperglycemia, and electrolyte disturbance between the two groups (all P>0.05). There was no significant difference in the incidence of bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), necrotizing enterocolitis (NEC), intra-ventricular hemorrhage (IVH) and other complications in both groups (all P>0.05).  Conclusion  Compared with low-dose caffeine citrate, high-dose caffeine citrate has a higher success rate of extubation, improves the respiratory function of preterm infants with AOP, and doesn't increase significantly in adverse reactions, which have clinical application meaning.

     

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