Volume 19 Issue 12
Dec.  2021
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(12): 2084-2087
HE Yi, PANG Jian-yue, LIU Yu-jia, DENG Ya-jie, LIU Yu-xia, LI Heng-fen. Levels of plasma myelin-associated proteins and inflammatory factors in patients with major depressive disorder[J]. Chinese Journal of General Practice, 2021, 19(12): 2084-2087. doi: 10.16766/j.cnki.issn.1674-4152.002243
Citation: HE Yi, PANG Jian-yue, LIU Yu-jia, DENG Ya-jie, LIU Yu-xia, LI Heng-fen. Levels of plasma myelin-associated proteins and inflammatory factors in patients with major depressive disorder[J]. Chinese Journal of General Practice, 2021, 19(12): 2084-2087. doi: 10.16766/j.cnki.issn.1674-4152.002243
shu

Levels of plasma myelin-associated proteins and inflammatory factors in patients with major depressive disorder

doi: 10.16766/j.cnki.issn.1674-4152.002243

  • Department of Psychiatry, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China

Funds:

 SB201901012

  • Received Date: 2021-01-26
    Available Online: 2022-03-02
    Abstract
  •   Objective  To compare the levels of peripheral plasma myelin-associated protein and inflammatory factors between patients with first-episode untreated and recurrent major depressive disorder and healthy people.  Methods  A total of 118 subjects in our hospital from March 2019 to May 2020 were recruited, including 40 patients with first-episode untreated major depressive disorder (first-episode group), 40 patients with recurrent major depressive disorder (recurrent group) and 38 healthy controls (control group). The levels of peripheral plasma myelin basic protein (MBP), myelin-associated glycoprotein, myelin oligodendrocyte glycoprotein, C-reactive protein, interleukin-6 and tumour necrosis factor-α (TNF-α) were measured by enzyme-linked immunosorbent assay. The 24-item Hamilton Depression scale (HAMD-24) was used to score the degree of depression in all patients.  Results  Statistically significant differences were observed in the levels of MBP amongst the three groups [recurrent group (2.32±0.95) ng/mL; first-episode group (1.92±0.91) ng/mL; control group (1.40±0.76) ng/mL] and TNF-α [recurrent group (8.49±5.45) ng/mL; first-episode group (6.30±4.71) ng/mL; control group (4.90±4.18) ng/mL, FMBP=10.824, P < 0.05; FTNF-α=5.510, P < 0.05]. The levels of MBP and TNF-α in the recurrent group were significantly higher than those in the first-episode group (tMBP=4.646, P < 0.05; tTNF-α=3.285, P < 0.05), whilst the levels of MBP and TNF-α in the recurrent group were significantly higher than those in the control group (tMBP=2.069, P < 0.05; tTNF-α=2.034, P < 0.05). The MBP of the first-episode group was significantly higher than that of the control group (tMBP=2.603, P < 0.05). No significant correlation was observed between the levels of myelin-associated protein, inflammatory factors and HAMD-24 scores.  Conclusion  The level of MBP in peripheral plasma may be an important biomarker to determine the prognosis of depression and the severity of pathological injury of the nerve myelin sheath. The level of TNF-α may be related to the recurrence of major depressive disorder.

     

    • FullText(HTML)
  • loading
    • References(19)
  • [1]
    DADI A F, MILLER E R, BISETEAN T A, et al. Global burden of antenatal depression and its association with adverse birth outcomes: An umbrella review[J]. BMC Public Health, 2020, 20(1): 173. doi: 10.1186/s12889-020-8293-9
    [2]
    MALHI G, MANN J. Depression[J]. The Lancet, 2018, 392(10161): 2299-2312. doi: 10.1016/S0140-6736(18)31948-2
    [3]
    NOBIS A, ZALEWSKI D, WASZKIEWICZ N. Peripheral markers of depression[J]. J Clin Med, 2020, 9: 3793. doi: 10.3390/jcm9123793
    [4]
    BYRNE M L, WHITTLE S, ALLEN N B. The role of brain structure and function in the association between inflammation and depressive symptoms: A systematic review[J]. Psychosom Med, 2016, 78(4): 389-400. doi: 10.1097/PSY.0000000000000311
    [5]
    SHIMIZU T, OSANAI Y, IKENAKA K. Oligodendrocyte-neuron interactions: Impact on myelination and brain function[J]. Neurochem Res, 2018, 43(1): 190-194. doi: 10.1007/s11064-017-2387-5
    [6]
    BODA E. Myelin and oligodendrocyte lineage cell dysfunctions: New players in the etiology and treatment of depression and stress-related disorders[J]. Eur J Neurosci, 2021, 53(1): 281-297. doi: 10.1111/ejn.14621
    [7]
    张作记. 行为医学量表手册[M]. 北京: 中华医学电子音像出版社, 2001: 225-227, 285-287.
    [8]
    张瀚迪, 方泽漫, 吴彩茹, 等. 慢性不可预测应激对铜腙诱导的小鼠脱髓鞘损伤及抑郁样行为的影响[J]. 中华行为医学与脑科学杂志, 2016, 25(10): 871-876. doi: 10.3760/cma.j.issn.1674-6554.2016.10.002
    [9]
    WILLIAMS L M. Precision psychiatry: A neural circuit taxonomy for depression and anxiety[J]. Lancet Psychiatry, 2016, 3(5): 472-480. doi: 10.1016/S2215-0366(15)00579-9
    [10]
    LU Y, ZHOU S, FAN C X, et al. Higher inflammation and cerebral white matter injury associated with cognitive deficit in asthmatic patients with depression[J]. J Asthma, 2020. DOI: 10.1080/02770903.2020.1853155.
    [11]
    吴玉华, 王晓红, 王蒙, 等. 少突胶质细胞、髓鞘碱性蛋白与抑郁症的相关性研究进展[J]. 神经疾病与精神卫生, 2016, 16(6): 732-734. doi: 10.3969/j.issn.1009-6574.2016.06.029
    [12]
    张珊, 赵静洁, 李丽. 免疫炎症与抑郁症[J]. 中华行为医学与脑科学杂志, 2019, 28(7): 660-665. doi: 10.3760/cma.j.issn.1674-6554.2019.07.017
    [13]
    CASSIERS L L M, NIEMEGEERS P, FRANSEN E, et al. Neuroendocrine and inflammatory effects of childhood trauma following psychosocial and inflammatory stress in women with remitted major depressive disorder[J]. Brain Sci, 2019, 9(12): 375. doi: 10.3390/brainsci9120375
    [14]
    CASSANO P, BUI E, ROGERS A H, et al. Inflammatory cytokines in major depressive disorder: A case-control study[J]. Aust N Z J Psychiatry, 2017, 51(1): 23-31. doi: 10.1177/0004867416652736
    [15]
    CARVALHO A F, SOLMI M, SANCHES M, et al. Evidence-based umbrella review of 162 peripheral biomarkers for major mental disorders[J]. Transl Psychiatry, 2020, 10(1): 152. http://diposit.ub.edu/dspace/bitstream/2445/174163/1/700808.pdf
    [16]
    LIU J J, WEI Y B, STRAWBRIDGE R, et al. Peripheral cytokine levels and response to antidepressant treatment in depression: A systematic review and meta-analysis[J]. Mol Psychiatry, 2020, 25(2): 339-350. doi: 10.1038/s41380-019-0474-5
    [17]
    MILLER E S, SAKOWICZ A, ROY A, et al. Plasma and cerebrospinal fluid inflammatory cytokines in perinatal depression[J]. Am J Obstet Gynecol, 2019, 220(3): 271. e1-271. e10. doi: 10.1016/j.ajog.2018.12.015
    [18]
    刘敏, 杜巧荣, 王禹辰, 等. 抑郁症患者人格、应对方式和抑郁严重程度的关系[J]. 中国健康心理学杂志, 2020, 28(6): 801-805. https://www.cnki.com.cn/Article/CJFDTOTAL-JKXL202006001.htm
    [19]
    谢军, 耿峰, 董毅, 等. 抑郁症患者童年期虐待与自我病耻感水平的相关性研究[J]. 中华全科医学, 2019, 17(7): 1171-1173. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201907032.htm
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (165) PDF downloads(1) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return