Volume 19 Issue 12
Dec.  2021
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Article Navigation >  Chinese Journal of General Practice  > 2021  >  19(12): 2132-2135, 2140
TAN Kai-yu, LIU Dan, LIU Hua-yun, TANG Xin-hui. Risk prediction of venous thromboembolism associated with gynaecologic cancer on the basis of the COMPASS-CAT risk assessment model[J]. Chinese Journal of General Practice, 2021, 19(12): 2132-2135, 2140. doi: 10.16766/j.cnki.issn.1674-4152.002254
Citation: TAN Kai-yu, LIU Dan, LIU Hua-yun, TANG Xin-hui. Risk prediction of venous thromboembolism associated with gynaecologic cancer on the basis of the COMPASS-CAT risk assessment model[J]. Chinese Journal of General Practice, 2021, 19(12): 2132-2135, 2140. doi: 10.16766/j.cnki.issn.1674-4152.002254
shu

Risk prediction of venous thromboembolism associated with gynaecologic cancer on the basis of the COMPASS-CAT risk assessment model

doi: 10.16766/j.cnki.issn.1674-4152.002254
  • 1.

    Xiangya School of Nursing, Central South University, Changsha, Hunan 410013, China

Funds:

 2019JJ80091

  • Received Date: 2021-02-18
    Available Online: 2022-03-02
    Abstract
  •   Objective  To explore the value of the COMPASS-CAT model and new model in predicting the risk of venous thrombosis associated with gynaecological malignancies.  Methods  From January 2015 to June 2020, 161 patients with gynaecological malignancies who were hospitalised with venous thromboembolism (VTE) in Hunan Cancer Hospital were enrolled. A total of 322 patients in the control group were selected according to the time matching 1 ∶ 2. The clinical data of the two groups of patients were collected. The risk factors of VTE related to gynaecological malignancies were analysed. A new model was constructed, and the receiver operating characteristic (ROC) curve was drawn and compared with the original COMPASS-CAT assessment model.  Results  The comparison between the two groups of patients in age, tumour stage, hypertension, hyperlipidaemia, diabetes, menopausal status, history of VTE, history of blood transfusion, central venous catheter, chemotherapy, platelet count and D-dimer showed statistically significant differences (all P < 0.05). Multivariate analysis showed that menopausal status, history of blood transfusion, chemotherapy and D-dimer≥0.55 μg/mL are independent risk factors for VTE related to gynaecological malignancies (all P < 0.05). The sensitivity of the new model was 75.8%, the specificity was 67.7%, and the Youden index was 0.435. The areas under the ROC curve (AUCs) of the two models were 0.698 (95% CI: 0.647-0.750) and 0.768 (95% CI: 0.723-0.813). Compared with the COMPASS-CAT model, the AUC area of the new model increased by 0.07 (P < 0.001).  Conclusion  The newly constructed COMPASS-CAT thrombosis risk assessment model has a high level of risk prediction for the formation of VTE related to gynaecological malignancies and improves the accuracy of identifying patients at high risk of thrombosis.

     

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