Volume 20 Issue 1
Jan.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(1): 8-10, 124
GU Ting, LIU Xiao-qing, CAO Feng, ZHANG Feng-bo. Serum expression levels and clinical significance of miR-483-5p in elderly patients with gastric cancer[J]. Chinese Journal of General Practice, 2022, 20(1): 8-10, 124. doi: 10.16766/j.cnki.issn.1674-4152.002263
Citation: GU Ting, LIU Xiao-qing, CAO Feng, ZHANG Feng-bo. Serum expression levels and clinical significance of miR-483-5p in elderly patients with gastric cancer[J]. Chinese Journal of General Practice, 2022, 20(1): 8-10, 124. doi: 10.16766/j.cnki.issn.1674-4152.002263
shu

Serum expression levels and clinical significance of miR-483-5p in elderly patients with gastric cancer

doi: 10.16766/j.cnki.issn.1674-4152.002263
  • 1.

    Clinical Test Lab, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China

Funds:

 81860352

  • Received Date: 2021-03-21
    Available Online: 2022-03-03
    Abstract
  •   Objective  To investigate the relative expression levels of serum miR-483-5p and its clinical significance in elderly patients with gastric cancer.  Methods  A total of 65 elderly patients with gastric cancer and 40 healthy individuals were enrolled in the First Affiliated Hospital of Xinjiang Medical University between January 1, 2017, and January 1, 2019. The difference in the relative expression levels of serum miR-483-5p amongst the subjects was detected and compared by RT-PCR. The relationship between the relative expression levels of serum miR-483-5p and clinical characteristics of elderly patients with gastric cancer was also analysed. The influencing factors affecting the relative expression levels of serum miR-483-5p were analysed by Logistic regression analysis. The clinical efficacy of miR-483-5p in the diagnosis of gastric cancer was analysed by the receiver operating characteristic (ROC) curve.  Results  Compared with the control group, the relative expression levels of serum miR-483-5p in elderly patients with gastric cancer were significantly higher (P < 0.001). The invasion levels (OR=4.123), TNM stage (OR=3.548) and lymph node metastasis (OR=4.015) were considered as the risk factors for the increased serum relative expression levels of miR-483-5p in elderly patients with gastric cancer. The ROC curve showed that the relative expression levels of serum miR-483-5p had a high clinical efficacy in the diagnosis of gastric cancer. Therefore, at a cutoff value of 0.812, the sensitivity and specificity were 91.2% and 95.3%, respectively.  Conclusion  The serum relative expression levels of miR-483-5p in elderly patients with gastric cancer are significantly high and related to the clinical characteristics. Therefore, miR-483-5p may be considered as a potential biomarker for gastric cancer screening.

     

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