Value of FDG-PET/CT in the assessment of brain function and its risk factors in patients with acute cerebrovascular disease and consciousness disorder

ZHANG Chao; YE Yu-ping; CUI Ke; WANG Jin-dong; ZHAO Hui; SONG Wei-jun

doi:10.16766/j.cnki.issn.1674-4152.002275

Volume 20 Issue 1

Jan. 2022

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Article Navigation > Chinese Journal of General Practice > 2022 > 20(1): 54-58

ZHANG Chao, YE Yu-ping, CUI Ke, WANG Jin-dong, ZHAO Hui, SONG Wei-jun. Value of FDG-PET/CT in the assessment of brain function and its risk factors in patients with acute cerebrovascular disease and consciousness disorder[J]. Chinese Journal of General Practice, 2022, 20(1): 54-58. doi: 10.16766/j.cnki.issn.1674-4152.002275

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ZHANG Chao, YE Yu-ping, CUI Ke, WANG Jin-dong, ZHAO Hui, SONG Wei-jun. Value of FDG-PET/CT in the assessment of brain function and its risk factors in patients with acute cerebrovascular disease and consciousness disorder[J]. Chinese Journal of General Practice, 2022, 20(1): 54-58. doi: 10.16766/j.cnki.issn.1674-4152.002275

Citation:

ZHANG Chao, YE Yu-ping, CUI Ke, WANG Jin-dong, ZHAO Hui, SONG Wei-jun. Value of FDG-PET/CT in the assessment of brain function and its risk factors in patients with acute cerebrovascular disease and consciousness disorder[J]. Chinese Journal of General Practice, 2022, 20(1): 54-58. doi: 10.16766/j.cnki.issn.1674-4152.002275

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Value of FDG-PET/CT in the assessment of brain function and its risk factors in patients with acute cerebrovascular disease and consciousness disorder

doi: 10.16766/j.cnki.issn.1674-4152.002275

Department of Severe Medicine, Taizhou Hospital of Zhejiang Province, Taizhou, Zhejiang 317000, China

Funds:

2019PY091

Received Date: 2021-03-12
Available Online: 2022-03-03

Abstract

Abstract

Objective To investigate the value of fluoride deoxyglucose (FDG)-PET/CT in the assessment of brain function in patients with acute cerebrovascular disease with consciousness disorder and analyse its risk factors. Methods A total of 170 patients with acute cerebrovascular disease and consciousness disorder, who were treated in our hospital from December 2015 to December 2020, were selected as the research objects, and they were divided into the consciousness recovery group (73 cases) and the unconsciousness group (97 cases) based on the scores of the Revised Coma Recovery Scale (CRS-R) at the time of discharge from the hospital. The clinical data were collected. FDG-PET/CT examination was performed, and the standard uptake values (SUVs) of different brain regions of interest on the left and right sides were measured. The ROC curve was used to analyse the evaluation value of SUV in different brain regions of interest for the recovery of consciousness in patients with acute cerebrovascular disease, and the multivariate Logistic regression model was used to analyse the risk factors affecting the recovery of consciousness. Results The CRS-R score and SUVs of the parietal lobe, occipital lobe, temporal lobe, frontal lobe, thalamus, cerebellum and basal ganglia in the unrecovered consciousness group were significantly lower than those in the recovered consciousness group (all P < 0.05), but the composition ratio of the hydrocephalus in the recovered consciousness group was significantly higher than that in the consciousness recovery group (P < 0.05). No statistically significant difference in SUVs of the parietal lobe, occipital lobe, temporal lobe, frontal lobe, thalamus, cerebellum and basal ganglia was found between the left and right brain of patients with the unconsciousness group (all P>0.05). The area under the curve of the combination of SUVs in different brain regions of interest in the assessment of the recovery of consciousness in patients with acute cerebrovascular disease was higher than that of SUV of the parietal lobe, occipital lobe, temporal lobe, frontal lobe, thalamus, cerebellum and basal ganglia alone (all P < 0.05). The sensitivity was 96.90%, and the specificity was 85.10%. The SUVs of the parietal lobe, occipital lobe, temporal lobe, frontal lobe, thalamus, cerebellum and basal ganglia were considered as risk factors affecting the recovery of consciousness in patients with acute cerebrovascular disease (all P < 0.05). Conclusion FDG-PET/CT examination is important to assess the brain function of patients with consciousness disorder and acute cerebrovascular disease.
- Acute cerebrovascular disease,
- Fluoride deoxyglucose,
- Positron emission computed tomography,
- Computed tomography,
- Consciousness disorder

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References

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Value of FDG-PET/CT in the assessment of brain function and its risk factors in patients with acute cerebrovascular disease and consciousness disorder

doi: 10.16766/j.cnki.issn.1674-4152.002275