Volume 20 Issue 1
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NI Zhe, LIU Lu. Clinical effect and neuroendocrine effect of low-frequency repetitive transcranial stimulation on patients with primary insomnia[J]. Chinese Journal of General Practice, 2022, 20(1): 62-64. doi: 10.16766/j.cnki.issn.1674-4152.002277
Citation: NI Zhe, LIU Lu. Clinical effect and neuroendocrine effect of low-frequency repetitive transcranial stimulation on patients with primary insomnia[J]. Chinese Journal of General Practice, 2022, 20(1): 62-64. doi: 10.16766/j.cnki.issn.1674-4152.002277
shu

Clinical effect and neuroendocrine effect of low-frequency repetitive transcranial stimulation on patients with primary insomnia

doi: 10.16766/j.cnki.issn.1674-4152.002277
  • 1.

    Psychological Measurement Room, Hangzhou Seventh People's Hospital, Hangzhou, Zhejiang 310013, China

Funds:

 2020KY223

  • Received Date: 2021-05-08
    Available Online: 2022-03-03
    Abstract
  •   Objective  To explore the clinical effects and neuroendocrine effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) on patients with primary insomnia (PI) and the mechanism of rTMS for clinical application.  Methods  A total of 100 patients with PI admitted to our hospital from July 2019 to July 2020 were selected as the research objects and randomly divided into the observation group (50 cases) and control group (50 cases) using the random number table method. The control group was treated with alternating magnetic field therapy, and the observation group was treated with rTMS therapy. The PSQI scores, glycine, glutamate and GABA levels were compared between the two groups before and after treatment.  Results  The PSQI score of the two groups had an inter-group effect (P < 0.05). The treatment effect of the observation group was better than that of the control group, and the total effective rate of treatment was higher than that of the observation group (96.00% vs. 74.00%; χ2=9.490, P=0.002). An inter-group effect on neurotransmitter levels was observed (all P < 0.05), the improvement effect of the observation group was better than that of the control group. In addition, a time effect (P < 0.05) and an interaction effect between grouping and time (P < 0.05) were observed between the two groups. The levels of each neurotransmitter of the patients could change over time, and the effect of the time factor was more significant in the observation group.  Conclusion  rTMS has evident therapeutic effects on patients with PI. Furthermore, improving the sleep state of patients can simultaneously regulate neuroendocrine levels, which has certain clinical application value.

     

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