Volume 20 Issue 1
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MAO Xiao-qiang, CHEN Yu, JIN Jing. Value of serum procalcitonin in the pathogenic classification of bacterial infection in emergency patients[J]. Chinese Journal of General Practice, 2022, 20(1): 65-67, 75. doi: 10.16766/j.cnki.issn.1674-4152.002278
Citation: MAO Xiao-qiang, CHEN Yu, JIN Jing. Value of serum procalcitonin in the pathogenic classification of bacterial infection in emergency patients[J]. Chinese Journal of General Practice, 2022, 20(1): 65-67, 75. doi: 10.16766/j.cnki.issn.1674-4152.002278
shu

Value of serum procalcitonin in the pathogenic classification of bacterial infection in emergency patients

doi: 10.16766/j.cnki.issn.1674-4152.002278
  • 1.

    Department of Emergency, Quzhou People's Hospital, Quzhou, Zhejiang 324000, China

Funds:

 2017KY699

  • Received Date: 2020-08-10
    Available Online: 2022-03-03
    Abstract
  •   Objective  To explore the value of serum procalcitonin (PCT) in the pathogen classification of bacterial infection in emergency patients and to provide reference for rational drug use in clinical antibacterial treatment.  Methods  A total of 240 infectious patients were selected in the Emergency Department of our hospital, and 120 healthy people were also selected for this study in the physical examination centre. Enzyme-linked immunosorbent assay was used to quantitatively detect serum PCT concentration. The diagnostic test was designed to comprehensively evaluate the value of PCT in the pathogen classification of bacterial infection in emergency patients, including the diagnostic test in the control group and bacterial infection group, diagnostic tests in gram-positive and gram-negative patients.  Results  The concentration of serum PCT was higher in the bacterial infection group than in the control group (P < 0.05). The PCT concentration in the gram-negative group was significantly higher than that in the gram-positive group. Results of diagnostic test between the bacterial infection and control groups showed that the area under AUC curve was 0.978 (95% CI: 0.958-0.991, P < 0.001), with a sensitivity of 91.5% and a specificity of 99.4% on the best cut-off value of 1.36 ng/mL. Diagnostic test results between gram-positive and gram-negative bacterial infection patients were that the area under AUC curve was 0.817 (95% CI: 0.757-0.868, P < 0.001), with a sensitivity of 80.0% and a specificity of 97.3% when the best cut-off value was 3.61 ng/mL.  Conclusion  Serum PCT is a good biomarker for pathogen classification in bacterial infection, and it may serve as a reference for the rational use of antibacterial drugs.

     

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