Volume 20 Issue 1
Jan.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(1): 99-103
AN Zhe, LI Si-peng, ZHANG Ni, DONG Wei, MENG Hao, LIU Hai-long, ZHOU Yuan, GUO Zhi, QIN Rui-hong, ZHU Huan-ge, SONG Lin-lan. Epidemiological study on the HBV-M results in infants under 1 year of age in Xi'an area[J]. Chinese Journal of General Practice, 2022, 20(1): 99-103. doi: 10.16766/j.cnki.issn.1674-4152.002287
Citation: AN Zhe, LI Si-peng, ZHANG Ni, DONG Wei, MENG Hao, LIU Hai-long, ZHOU Yuan, GUO Zhi, QIN Rui-hong, ZHU Huan-ge, SONG Lin-lan. Epidemiological study on the HBV-M results in infants under 1 year of age in Xi'an area[J]. Chinese Journal of General Practice, 2022, 20(1): 99-103. doi: 10.16766/j.cnki.issn.1674-4152.002287
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Epidemiological study on the HBV-M results in infants under 1 year of age in Xi'an area

doi: 10.16766/j.cnki.issn.1674-4152.002287

  • Department of Clinical Laboratory, the the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China

Funds:

 2018SF-152

 YJ(QN)201534

  • Received Date: 2020-04-09
    Available Online: 2022-03-03
    Abstract
  •   Objective  To analyse the results and characteristics of hepatitis B virus markers (HBV-M) in infants before 1 year of age retrospectively.  Methods  From January 2019 to November 2019, 815 infants and 219 mothers with HBV-M were examined in the clinical laboratory of the Second Affiliated Hospital of Xi'an Jiaotong University. The infants were divided into three groups: group 1, which included infants aged 7-11 months; group 2, which included infants aged 1-6 months; and group 3, which included infants aged below 1 month. The HBV-M quantitative test was performed by chemiluminescent immunoassay with Abbott's Alinity immunoassay instrument. All samples of HBsAg were centrifuged at high speed and rechecked, and the rechecked results were taken as the final results.  Results  The positive rates of HBsAg were 0.00%, 0.47% and 6.66%, respectively, in the three groups. The positive rates of anti-HBs in the three groups were 94.29%, 84.65% and 66.06%, respectively. The positive rates of anti-HBc in the three groups were 6.67%, 20.47% and 27.27%, respectively. The HBsAg positive rate was 0% in infants born from 8 HBsAg-positive mothers. The consistency rate was 85.53% between 76 HBV-M-negative mothers and their infants, and consistency rates of anti-HBs, anti-HBc and anti-HBe were 100.00%, 95.00% and 77.27%, respectively. The main features of HBV-M in 31 HBsAg-positive infants were: HBsAg negative in their mothers, HBsAg level 0.19 IU/mL (0.05-0.54 IU/mL), anti-HBc negative, regular follow-up HBsAg can turn negative, HBV vaccine and NHB may be the main reason for false positive, the detection time does not exceed 10 days after vaccination.  Conclusion  The HBSAG positive rate and anti-HB positive rate of 7-11-month-old infants are the lowest, which indicates that the protective effect of HBV vaccine is good at present HBsAg was mainly found in 1-10-day-old newborns, which could turn negative during regular follow-up.

     

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