Volume 20 Issue 1
Jan.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(1): 104-108
DU Lin-na, LIU Shan, GUO Yan, WANG Min-juan. Association and research progress between potentially inappropriate medication and the risk factors of frailty in the elderly[J]. Chinese Journal of General Practice, 2022, 20(1): 104-108. doi: 10.16766/j.cnki.issn.1674-4152.002288
Citation: DU Lin-na, LIU Shan, GUO Yan, WANG Min-juan. Association and research progress between potentially inappropriate medication and the risk factors of frailty in the elderly[J]. Chinese Journal of General Practice, 2022, 20(1): 104-108. doi: 10.16766/j.cnki.issn.1674-4152.002288
shu

Association and research progress between potentially inappropriate medication and the risk factors of frailty in the elderly

doi: 10.16766/j.cnki.issn.1674-4152.002288

  • Department of General Medicine, the First Affiliated Hospital of Xi'an Medical College, Xi'an, Shaanxi 710000, China

Funds:

 2018D076

  • Received Date: 2020-12-26
    Available Online: 2022-03-03
    Abstract
  • China is entering the ageing stage, and elderly pharmacokinetics and pharmacodynamics very easily causes drug accumulation in body drug-related adverse reactions. Multi-drug use and potential inappropriate medication (PIM) are at high risk in the elderly, and the development of a catalogue of PIM can effectively screen the drugs causing adverse reactions in the elderly to regulate their rational use of drugs. Frailty is a common disease in the elderly, which can lead to high hospitalisation rate, prolonged hospitalisation, disability, and death. It is one of the major public-health problems in China. As the need for health becomes more common, the perception of frailty becomes more important. Age, income, lifestyle, health status, nutrition status, multiple drug use, and so on are the risk factors of frailty. The identification of risk factors can lead to a more comprehensive and systematic cognitive frailty for effective intervention at an early stage, delay the occurrence and development, improve the quality of life of the elderly, and reduce medical burden. Many studies have shown that a significant correlation existed between PIM and frailty and the risk factors of frailty, but few relevant literature exists in China. In this study, the correlations amongst physical function, cognitive function, sleep disorder, malnutrition, and other aspects of the elderly are reviewed through relevant literature at home and abroad. To standardise the rational use of drugs in the elderly, we should pay more attention to the PIM, the individual treatment, and the detection of adverse drug reactions. Our findings can serve as a reference for the research on China's declination.

     

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