Volume 20 Issue 1
Jan.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(1): 141-143, 164
ZENG Wei, LIU Yi, LI Wen-ting, ZHU Jin-feng. Functional enrichment and pathway analysis of differential expression of exosome lncRNA in colorectal cancer[J]. Chinese Journal of General Practice, 2022, 20(1): 141-143, 164. doi: 10.16766/j.cnki.issn.1674-4152.002297
Citation: ZENG Wei, LIU Yi, LI Wen-ting, ZHU Jin-feng. Functional enrichment and pathway analysis of differential expression of exosome lncRNA in colorectal cancer[J]. Chinese Journal of General Practice, 2022, 20(1): 141-143, 164. doi: 10.16766/j.cnki.issn.1674-4152.002297
shu

Functional enrichment and pathway analysis of differential expression of exosome lncRNA in colorectal cancer

doi: 10.16766/j.cnki.issn.1674-4152.002297
  • 1.

    First Department of Lung Cancer Chemotherapy, the Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, China

Funds:

 2018D01C255

  • Received Date: 2021-02-03
    Available Online: 2022-03-03
    Abstract
  •   Objective  To explore the role of differential expression of exosome lncRNA and its regulated signal pathway in the occurrence and development of colorectal cancer and provide a new target for the diagnosis and treatment of colorectal cancer.  Methods  The linear regression model package limma of R software was used to analyse the differential expression of lncRNA and mRNA. By calculating the Pearson correlation coefficient between differentially expressed lncRNA and mRNA, their co-expression was obtained. The positive co-expression of lncRNA-mRNA was screened by using a correlation coefficient. Go function and KEGG pathway enrichment of mRNA co-expressed with lncRNA were analysed to indirectly predict the function of lncRNA.  Results  A total of 202 differentially expressed exosome lncRNAs and 1014 exosome mRNA were screened from 32 healthy volunteers and 12 colorectal cancer patients. Ten pairs of lncRNA-mRNA co-expression were verified. Functional enrichment of mRNA co-expressed by lncRNA showed that differentially expressed exosome lncRNA may be closely related to B cell receptor signal pathway, NF-KB signal pathway, JAK-STAT signal pathway, antigen processing and presentation signal pathway and NOD-like receptor signal pathway activation.  Conclusion  In-depth exploration of differential expression, functional enrichment and pathway activation of exosome lncRNA in colorectal cancer is important to provide new ideas for the diagnosis and treatment of colorectal cancer.

     

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