Volume 20 Issue 2
Feb.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(2): 209-211, 232
SU Chuan-yong, TAO Die-hong, REN Li, GUO Shu-ping, ZHOU Wen-fei, WU Hai-ying, JIANG Hui-fang. Correlation between peripheral blood neutrophil to lymphocyte ratio level and T lymphocyte subsets in patients with multiple myeloma and its impact on prognosis[J]. Chinese Journal of General Practice, 2022, 20(2): 209-211, 232. doi: 10.16766/j.cnki.issn.1674-4152.002314
Citation: SU Chuan-yong, TAO Die-hong, REN Li, GUO Shu-ping, ZHOU Wen-fei, WU Hai-ying, JIANG Hui-fang. Correlation between peripheral blood neutrophil to lymphocyte ratio level and T lymphocyte subsets in patients with multiple myeloma and its impact on prognosis[J]. Chinese Journal of General Practice, 2022, 20(2): 209-211, 232. doi: 10.16766/j.cnki.issn.1674-4152.002314
shu

Correlation between peripheral blood neutrophil to lymphocyte ratio level and T lymphocyte subsets in patients with multiple myeloma and its impact on prognosis

doi: 10.16766/j.cnki.issn.1674-4152.002314

  • Department of Hematology, Zhejiang Tongde Hospital, Hangzhou, Zhejiang 310012, China

Funds:

 2019KY049

 2A11952

  • Received Date: 2021-03-17
    Available Online: 2022-03-04
    Abstract
  •   Objective  To investigate the correlation between the ratio of peripheral blood neutrophil to lymphocyte (NLR) level and T lymphocyte subsets in patients with multiple myeloma (MM) and its effect on prognosis.  Methods  Eighty patients with MM who were treated in Zhejiang Tongde Hospital from June 2016 to January 2018 were selected as the MM group; 60 healthy people who were examined in our hospital during the same period were selected as the healthy control group. The levels of NLR, peripheral blood T cell subsets and NK cells were compared between the two groups. Pearson method was used to analyse the correlation between NLR and T cell subsets levels in the MM group. In addition, the patients with MM were divided into the high NLR level group (NLR≥2.69; 38 cases) and low NLR level group (NLR < 2.69; 42 cases). The survival curves were drawn, and the survival rates were compared between the two groups.  Results  The levels of NLR and CD8+ in the MM group were significantly higher than those in the healthy control group [2.69±0.74 vs. 1.72±0.45, (44.34±5.04)% vs. (25.36±3.54)%, t=9.614, 26.133, all P < 0.05], the levels of CD3+, CD4+ and CD4+/CD8+ in the MM group were obviously lower than those in the healthy control group (all P < 0.05), and no significant difference in the level of NK cells was found between the two groups (P>0.05). In the patients with MM, NLR negatively correlated with CD3+, CD4+, CD4+/CD8+ (r=-0.483, -0.481, -0.595, all P < 0.05) and positively correlated with CD8+ (r=0.318, P < 0.05). The two-year survival rate and the two-year progression-free survival rate of the high NLR group was obviously lower than those of the low NLR group (all P < 0.05).  Conclusion  The CD3+, CD4+ and CD4+/CD8+ levels in the patients with MM are obviously lower than those in healthy people, and the NLR and CD8+ levels in the patients with MM are obviously higher than those in healthy people. The level of NLR is closely related to the immune function of patients. High NLR levels and abnormal expression of peripheral T lymphocyte subsets suggest a poor prognosis in patients with MM.

     

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