Volume 20 Issue 2
Feb.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(2): 233-236
LUO Jian, XU Zhao-jun. Relationship between plasma B-type natriuretic peptide and severity of craniocerebral injury and its predictive effect on cerebral heart syndrome[J]. Chinese Journal of General Practice, 2022, 20(2): 233-236. doi: 10.16766/j.cnki.issn.1674-4152.002320
Citation: LUO Jian, XU Zhao-jun. Relationship between plasma B-type natriuretic peptide and severity of craniocerebral injury and its predictive effect on cerebral heart syndrome[J]. Chinese Journal of General Practice, 2022, 20(2): 233-236. doi: 10.16766/j.cnki.issn.1674-4152.002320
shu

Relationship between plasma B-type natriuretic peptide and severity of craniocerebral injury and its predictive effect on cerebral heart syndrome

doi: 10.16766/j.cnki.issn.1674-4152.002320
  • 1.

    Department of Critical Care Medicine, Quzhou People's Hospital, Quzhou, Zhejiang 324000, China

Funds:

 2018KY688

  • Received Date: 2021-02-01
    Available Online: 2022-03-04
    Abstract
  •   Objective  To analyse the relationship between plasma B-type natriuretic peptide (BNP) and the severity of craniocerebral injury and its predictive effect on cerebral heart syndrome.  Methods  A total of 186 patients with craniocerebral injury admitted to our hospital from January 2016 to October 2020 were selected as participants. They were divided into mild, medium and severe groups according to the Glasgow Coma Score (GCS) on admission. The changes in plasma BNP levels in each group were observed. The levels of plasma BNP, neuron-specific enolase (NSE), myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in the three groups were compared. Area under receiver operating characteristic (ROC) curve (AUC) was used to evaluate the predictive efficacy of plasma BNP in cerebral heart syndrome.  Results  The BNP levels of patients with craniocerebral injury on the 1st, 3rd and 7th day after injury are (74.75±21.54)ng/L, (123.89±51.47)ng/L and (93.00±31.28)ng/L.The plasma BNP levels in mild, moderate and severe groups increased on day 1 after injury, peaked on day 3, and decreases significantly on day 7, with statistical significance(P < 0.05). The more severe the head injury was, the lower the GCS score was on the 3rd day after injury and the higher the plasma BNP, NSE, MBP and GFAP levels were; the difference was statistically significant (all P < 0.05). Pearson correlation analysis showed that the levels of BNP, NSE, MBP and GFAP negatively correlated with GCS score at the 3rd day after craniocerebral injury (all P < 0.05). Univariate and multivariate logistic regression analyses revealed that plasma BNP, NSE, MBP and GFAP were all independent predictors of cerebral heart syndrome (all P < 0.05). ROC curve analysis showed that the AUC of the 3rd day plasma BNP after craniocerebral injury was 0.924.  Conclusion  Plasma BNP level is related to the progression of craniocerebral injury and is effective in predicting cerebral heart syndrome. Thus, it is worthy of clinical attention.

     

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