Correlation analysis of white matter lesions and motor symptoms and non-motor symptoms in Parkinson's patients

WANG Wei; CAO Qing-hua; SUN Guang-ling; SU Hang

doi:10.16766/j.cnki.issn.1674-4152.002321

Volume 20 Issue 2

Feb. 2022

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Article Navigation > Chinese Journal of General Practice > 2022 > 20(2): 237-239

WANG Wei, CAO Qing-hua, SUN Guang-ling, SU Hang. Correlation analysis of white matter lesions and motor symptoms and non-motor symptoms in Parkinson's patients[J]. Chinese Journal of General Practice, 2022, 20(2): 237-239. doi: 10.16766/j.cnki.issn.1674-4152.002321

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WANG Wei, CAO Qing-hua, SUN Guang-ling, SU Hang. Correlation analysis of white matter lesions and motor symptoms and non-motor symptoms in Parkinson's patients[J]. Chinese Journal of General Practice, 2022, 20(2): 237-239. doi: 10.16766/j.cnki.issn.1674-4152.002321

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Correlation analysis of white matter lesions and motor symptoms and non-motor symptoms in Parkinson's patients

doi: 10.16766/j.cnki.issn.1674-4152.002321

Brain Center, the Affiliated Hospital of Medical School, NingBo University, NingBo, Zhejiang 315020, China

Funds:

2020KY875

Received Date: 2021-04-17
Available Online: 2022-03-04

Abstract

Abstract

Objective To investigate the effect of white matter lesion (WML) on motor and non-motor symptoms in patients with Parkinson disease (PD). Methods Total 148 patients with primary PD from the Affiliated Hospital of Ningbo University School of Medicine from May 2017 to April 2020 were selected and divided into WML group (83 cases) and non-WML group (65 cases) according to whether they were accompanied by WM. According to Fazekas score, there were 65 cases in WML 0 group, 25 cases in grade 1 group, 30 cases in grade 2 group and 28 cases in grade 3 group. The general data of WML group and non-WML group, PD score scale Ⅲ (UPDRS Ⅲ) and PD non-motor symptom questionnaire (NMSQ) of different WML grading groups were compared, and the relationship between WML and PD patients with motor symptoms and non-motor symptoms was analyzed by Logistic regression. Results The UPDRS Ⅲ score of the WML group was (25.52±4.24) points, which was higher than the (18.65±4.12) points of the non-WML group (t=9.905, P < 0.05), and the degree of dyskinesia was more serious than that of the non-WML group (χ²=50.776, P < 0.05). The NMSQ score of the non-WML group was (12.65±1.32) points, the NMSQ score of the WML group was (17.25±3.12) points, and the NMSQ score of the WML group was higher than that of the non-WML group (t=11.126, P < 0.05). The results of multivariate regression analysis showed that the higher the UPDRS Ⅲ score, the higher the proportion of severe H &Y staging, and the higher the NMSQ score were all risk factors for PD patients with severe WML staging (P < 0.05). Conclusion WML can increase PD motor symptoms and non-motor symptoms, and the degree of risk is related to the WML classification.
- Parkinson disease,
- White matter lesions,
- Motor symptoms,
- Non-motor symptoms,
- Correlation

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References

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Correlation analysis of white matter lesions and motor symptoms and non-motor symptoms in Parkinson's patients

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