Volume 20 Issue 2
Feb.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(2): 240-242
LIU Yi-hui, GUO Yan, FENG Hui, XU Hong, HAN Ying. Clinical observation of different hepatotoxic reactions of anti-tuberculosis drugs in the liver[J]. Chinese Journal of General Practice, 2022, 20(2): 240-242. doi: 10.16766/j.cnki.issn.1674-4152.002322
Citation: LIU Yi-hui, GUO Yan, FENG Hui, XU Hong, HAN Ying. Clinical observation of different hepatotoxic reactions of anti-tuberculosis drugs in the liver[J]. Chinese Journal of General Practice, 2022, 20(2): 240-242. doi: 10.16766/j.cnki.issn.1674-4152.002322
shu

Clinical observation of different hepatotoxic reactions of anti-tuberculosis drugs in the liver

doi: 10.16766/j.cnki.issn.1674-4152.002322
  • 1.

    Department of Liver Disease, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang 310003, China

Funds:

 2020ZB189

  • Received Date: 2021-03-14
    Available Online: 2022-03-04
    Abstract
  •   Objective  To observe the clinical characteristics of different hepatic toxicity in anti-tuberculosis treatment.  Methods  Retrospective analysis was performed on 90 cases of initially treated pulmonary tuberculosis in Hangzhou Red Cross Hospital. According to the different reactions of anti-tuberculosis drugs, the patients were divided into tolerance group, susceptible group and adaptive group, with 30 cases in each group. Age, gender, underlying diseases, alcohol consumption, duration of medication, type of liver injury and degree of liver injury were observed.  Results  The differences in age, basic liver disease and drug allergy history among the tolerance, susceptible and adaptation groups were statistically significant (F=7.193, χ2=6.398, χ2=8.580, all P < 0.05). No significant difference in gender and drinking history was found among the three groups (χ2=1.148, 2.917, all P>0.05). The incubation period of the adaptive group was significantly longer than that of the susceptible group [(4.39±1.24) weeks vs. (2.33±0.91) weeks], whereas the recovery period of the adaptive group was significantly shorter than that of the susceptible group [(2.28±0.90) weeks vs. (4.67±1.09)weeks, t=-5.666, 7.208, all P < 0.05]. The proportion of liver injury types in the two groups was significantly different(χ2=41.429, P < 0.001), and the proportion of liver injury degree in the two groups was significantly different (U=3.506, P=0.001).  Conclusion  The different reactions of anti-tuberculosis drugs in the liver are related to age, basic liver disease and drug allergy history but not related to gender and alcohol consumption. In the susceptible group, the short latency recovery is slow, whereas in the adaptive group, the long latency recovery is fast. In the susceptible group, hepatocyte injury is more common. In the adaptive group, biochemical abnormalities are more common. Mild and moderate liver injuries are common in both groups.

     

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