The correlation between peritoneal fibrosis and the levels of SGLT1, TGF-β1, and VEGF in peritoneal dialysis patients and its application value

WANG Chao-chao; LIN Yong-qiang; CHEN Tian-tian; ZHOU Ying; CAI Xiao-qiao; LIN Sheng-fen

doi:10.16766/j.cnki.issn.1674-4152.002325

Volume 20 Issue 2

Feb. 2022

Turn off MathJax

Article Contents

Article Navigation > Chinese Journal of General Practice > 2022 > 20(2): 251-254

WANG Chao-chao, LIN Yong-qiang, CHEN Tian-tian, ZHOU Ying, CAI Xiao-qiao, LIN Sheng-fen. The correlation between peritoneal fibrosis and the levels of SGLT1, TGF-β1, and VEGF in peritoneal dialysis patients and its application value[J]. Chinese Journal of General Practice, 2022, 20(2): 251-254. doi: 10.16766/j.cnki.issn.1674-4152.002325

Citation:

WANG Chao-chao, LIN Yong-qiang, CHEN Tian-tian, ZHOU Ying, CAI Xiao-qiao, LIN Sheng-fen. The correlation between peritoneal fibrosis and the levels of SGLT1, TGF-β1, and VEGF in peritoneal dialysis patients and its application value[J]. Chinese Journal of General Practice, 2022, 20(2): 251-254. doi: 10.16766/j.cnki.issn.1674-4152.002325

Citation:

WANG Chao-chao, LIN Yong-qiang, CHEN Tian-tian, ZHOU Ying, CAI Xiao-qiao, LIN Sheng-fen. The correlation between peritoneal fibrosis and the levels of SGLT1, TGF-β1, and VEGF in peritoneal dialysis patients and its application value[J]. Chinese Journal of General Practice, 2022, 20(2): 251-254. doi: 10.16766/j.cnki.issn.1674-4152.002325

PDF( 1090 KB)

The correlation between peritoneal fibrosis and the levels of SGLT1, TGF-β1, and VEGF in peritoneal dialysis patients and its application value

doi: 10.16766/j.cnki.issn.1674-4152.002325

1.
Nephrology Department, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, Zhejiang 325000, China

Funds:

LQ19H050002

Received Date: 2021-08-27
Available Online: 2022-03-04

Abstract

Abstract

Objective To investigate the correlation between peritoneal fibrosis and the levels of sodium-glucose transporter 1 (SGLT1), transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF) and its application value. Methods Twenty-five cases of patients with peritoneal fibrosis on maintenance hemodialysis were selected as study group, and 35 cases of peritoneal dialysis patients without peritoneal fibrosis were selected as the control group in Department of Nephrology, Wenzhou Integrated Traditional Chinese and Western Medicine Hospital from June 2012 to June 2021.The levels of SGLT1, TGF-β1 and VEGF of two groups were compared. The application value of SGLT1, TGF-β1, and VEGF of diagnosis of peritoneal fibrosis were analyzed by diagnosis of peritoneal fibrosis. Results The levels of SGLT [(128.85±22.58) pg/mL vs. (85.42±15.68) pg/mL], TGF-β1 [(432.32±54.18) pg/mL vs. (245.72±32.10) pg/mL], and VEGF [(903.25±61.45) ng/mL vs. (612.85±32.10) ng/mL] were statistically different between the two groups (all P < 0.05). The ROC curve analysis showed that the maximum area under the curve (AUC) were 0.865 (95% CI: 0.708-0.952), and the sensitivity and specificity were 85.02% and 82.14% when the three were diagnosed jointly. Conclusion Abnormally elevated levels of SGLT1, TGF-β1, and VEGF are closely related to the occurrence of peritoneal fibrosis. The levels of SGLT1, TGF-β1, and VEGF can effectively predict the occurrence of peritoneal fibrosis.
- Peritoneal dialysis,
- Peritoneal fibrosis,
- Sodium-glucose transporter 1,
- Transforming growth factor-β1,
- Vascular endothelial growth factor,
- Correlation

FullText(HTML)

References(22)

References

[1]	葛珊珊, 陈洪宇, 曾佳丽, 等. 腹膜透析患者容量超负荷、腹膜纤维化的中西医诊治[J]. 中国中西医结合肾病杂志, 2020, 21(2): 187-188. doi: 10.3969/j.issn.1009-587X.2020.02.034
[2]	毛艳, 卢丽, 赵黎, 等. 腹膜透析患者腹膜纤维化与腹透液中转化生长因子β1、白介素-6水平相关性研究[J]. 内科急危重症杂志, 2020, 26(1): 41-43. https://www.cnki.com.cn/Article/CJFDTOTAL-NKJW202001013.htm
[3]	童孟立. 腹膜透析患者腹膜纤维化发生机制及防治的研究进展[J]. 浙江医学, 2020, 42(6): 529-532. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJYE202006005.htm
[4]	陈胜江, 尚智伟, 刘一靖, 等. 超声引导穿刺活检诊断腹膜后纤维化[J]. 中国临床医学影像杂志, 2018, 29(1): 38-41. doi: 10.3969/j.issn.1008-1062.2018.01.010
[5]	林文珊, 周添标. 腹膜透析相关性腹膜纤维化发生机制及治疗新进展[J]. 实用医学杂志, 2019, 35(1): 4-9. doi: 10.3969/j.issn.1006-5725.2019.01.002
[6]	HUSAM M S, SUBHI J A, MUHAMMAD S K, et al. Effects of sodium-glucose cotransporter 1 and 2 inhibitors on cardiovascular and kidney outcomes in type 2 diabetes: A meta-analysis update[J]. Am Heart J, 2021, 233(2): 86-91.
[7]	XIE JL, HONG L, LIN S, et al. MicroRNA-302c modulates peritoneal dialysis-associated fibrosis by targeting connective tissue growth factor[J]. J Cell Mol Med, 2019, 23(4): 2372-2383. doi: 10.1111/jcmm.14029
[8]	YING F S, YAN H, BIN B C, et al. Vascular endothelial growth factor-mediated peritoneal neoangiogenesis in peritoneal dialysis[J]. Perit Dial Int, 2021, 2(5): 45-46.
[9]	李世军. 改善全球肾脏病预后组织(KDIGO)临床实践指南: 肾小球肾炎[J]. 肾脏病与透析肾移植杂志, 2012, 21(3): 260-267. doi: 10.3969/j.issn.1006-298X.2012.03.013
[10]	沈水娟, 王时敏, 官继超, 等. 单中心腹膜透析患者的转归及其退出原因分析[J]. 中华全科医学, 2019, 17(8): 1331-1334. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201908024.htm
[11]	谭巧灵, 赵昕怡, 陈彦蓉, 等. 钠-葡萄糖共同转运体2抑制剂对2型糖尿病患者胰岛素敏感性及血清GPC-4的影响[J]. 重庆医科大学学报, 2021, 46(9): 1100-1105. https://www.cnki.com.cn/Article/CJFDTOTAL-ZQYK202109022.htm
[12]	张倩, 孙丽娜, 聂春迎, 等. 腹膜透析相关性腹膜纤维化发生机制[J]. 中国中西医结合肾病杂志, 2019, 20(3): 265-267. doi: 10.3969/j.issn.1009-587X.2019.03.027
[13]	洪梦琪, 聂振宇, 陈正月, 等. 高糖透析液通过上调葡萄糖转运蛋白GLUT1和SGLT1促进腹膜纤维化[J]. 浙江大学学报, 2016, 45(6): 598-606.
[14]	GHEZZI C, LOO D D F, WRIGHT E M. Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2[J]. Diabetologia, 2018, 61(10): 2087-2097. doi: 10.1007/s00125-018-4656-5
[15]	郭淑婷, 唐阁, 李维. 腹膜透析致腹膜纤维化的发生机制及其防治的研究进展[J]. 辽宁中医杂志, 2018, 45(3): 651-653. https://www.cnki.com.cn/Article/CJFDTOTAL-LNZY201803061.htm
[16]	罗来敏, 张桂玲. 塑化剂对慢性肾衰大鼠模型和腹膜透析患者腹膜纤维化调控因子TGF-β1/Smads表达的影响[J]. 福建医科大学学报, 2018, 52(2): 90-96. https://www.cnki.com.cn/Article/CJFDTOTAL-FJYD201802006.htm
[17]	雷洋洋, 杨波, 裴明, 等. 扶肾方对尿毒症大鼠腹膜间充质TGF-β1、E-cadherin和α-SMA表达的影响[J]. 天津中医药, 2018, 35(7): 521-525. https://www.cnki.com.cn/Article/CJFDTOTAL-TJZY201807013.htm
[18]	卫志锋, 王琳琳, 冯季, 等. 甘草酸二胺对腹膜透析患者腹膜功能及TGF-β1、VEGF、CTGF水平的影响[J]. 山东医药, 2018, 58(5): 55-57. doi: 10.3969/j.issn.1002-266X.2018.05.018
[19]	HIRO S, KINA S, YASU K I, TING S, et al. Roles of the TGF-β1、VEGF-C pathway in fibrosis-related lymphangiogenesis[J]. Int J Mol Sci, 2018, 19(9): 2487-2489. doi: 10.3390/ijms19092487
[20]	QIAN X H, LU W, LU Y W, et al. miR-15a-5p suppresses peritoneal fibrosis induced by peritoneal dialysis via targeting VEGF in rats[J]. Ren Fail, 2020, 42(1): 932-943. doi: 10.1080/0886022X.2020.1811123
[21]	JUAN L, SHUANG X L, XIAN H G, et al. HIF1A and VEGF regulate each other by competing endogenous RNA mechanism and involve in the pathogenesis of peritoneal fibrosis[J]. Pathol Res Pract, 2019, 215(4): 644-652. doi: 10.1016/j.prp.2018.12.022
[22]	叶寅寅, 赵洪静, 徐海红. 腹膜透析相关性腹膜纤维化机制的研究进展[J]. 医学综述, 2017, 23(21): 4262-4266. doi: 10.3969/j.issn.1006-2084.2017.21.020

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1) / Tables(5)

Get Citation

PDF

XML

Article Metrics

Article views (216) PDF downloads(9)

The correlation between peritoneal fibrosis and the levels of SGLT1, TGF-β1, and VEGF in peritoneal dialysis patients and its application value

doi: 10.16766/j.cnki.issn.1674-4152.002325

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

The correlation between peritoneal fibrosis and the levels of SGLT1, TGF-β1, and VEGF in peritoneal dialysis patients and its application value

doi: 10.16766/j.cnki.issn.1674-4152.002325

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content