Volume 20 Issue 2
Feb.  2022
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Article Navigation >  Chinese Journal of General Practice  > 2022  >  20(2): 259-262
CHU Wei-hong, PENG Shao, MA Ying-ying, ZHANG Man, XU Li-yan, GAO Yi-wei, GAO Yuan, MIAO Xue-yan. Effect of vitamin D supplementation on FEV1%, FeNO and control level in children with uncontrolled bronchial asthma[J]. Chinese Journal of General Practice, 2022, 20(2): 259-262. doi: 10.16766/j.cnki.issn.1674-4152.002327
Citation: CHU Wei-hong, PENG Shao, MA Ying-ying, ZHANG Man, XU Li-yan, GAO Yi-wei, GAO Yuan, MIAO Xue-yan. Effect of vitamin D supplementation on FEV1%, FeNO and control level in children with uncontrolled bronchial asthma[J]. Chinese Journal of General Practice, 2022, 20(2): 259-262. doi: 10.16766/j.cnki.issn.1674-4152.002327
shu

Effect of vitamin D supplementation on FEV1%, FeNO and control level in children with uncontrolled bronchial asthma

doi: 10.16766/j.cnki.issn.1674-4152.002327

  • Department of Paediatrics, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China

Funds:

 18A320013

  • Received Date: 2021-05-21
    Available Online: 2022-03-04
    Abstract
  •   Objective  To explore the effect of vitamin D (VD) supplementation on forced expiratory volume for 1 second expressed as a percentage of the forced vital capacity (FEV1%), fractional exhaled nitric oxide (FeNO) and control level in children with uncontrolled asthma.  Methods  Children with uncontrolled asthma who visited the children's asthma clinic of the First Affiliated Hospital of Zhengzhou University from January 2018 to October 2019 were selected as study subjects and randomly divided into the observation and control groups. The observation group received inhaled glucocorticoid+β2 receptor agonist + leukotriene receptor antagonist+VD. The control group received the same treatment without VD. Serum 25 hydroxy vitamin D(25OHD), lung function and FeNO were tested, and clinical control level were evaluated at monthly follow-up for 3 months.  Results  (1) Statistical significance in FEV1% and FeNO was found between the two groups, between each time point and in interaction between group and time (FFEV1%=9.545, 600.842, 12.018, FFeNO=7.037, 1 118.111, 37.062, all P < 0.05). (2) At 1, 2 and 3 months of treatment, a significant difference in FEV1% was found between the two groups (tFEV1%=2.032, 2.310, 2.562, all P < 0.05). FEV1% increased faster in the observation group than in the control group. (3) The difference was significant at 1, 2 and 3 months (t=-2.332, -5.940, -5.024, all P < 0.05) in FeNO between the two groups. FeNO decreased faster in the observation group than in the control group. (4) The good control rate of the observation group was higher than that of the control group in the second month of treatment (51/20 vs. 28/32, χ2=8.602, P=0.003). There was no significant difference between the two groups in the first and third months (all P>0.05).  Conclusion  VD supplementation in children with uncontrolled asthma may increase FEV1% and decrease FeNO quickly and allow asthma control in advance.

     

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